Now showing items 1-14 of 14

    • A genome-wide association study identifies susceptibility variants for type 2 diabetes in Han Chinese. 

      Tsai, Fuu-Jen; Yang, Chi-Fan; Chen, Ching-Chu; Chuang, Lee-Ming; Lu, Chieh-Hsiang; Chang, Chwen-Tzuei; Wang, Tzu-Yuan; ... (16 authors) (PLoS Genet, 2010-02-19)
      To investigate the underlying mechanisms of T2D pathogenesis, we looked for diabetes susceptibility genes that increase the risk of type 2 diabetes (T2D) in a Han Chinese population. A two-stage genome-wide association (GWA) ...
    • CASP7 variants modify susceptibility to cervical cancer in Chinese women. 

      Shi, Ting-Yan; He, Jing; Wang, Meng-Yun; Zhu, Mei-Ling; Yu, Ke-Da; Shao, Zhi-Ming; Sun, Meng-Hong; ... (10 authors) (Scientific reports, 2015-01)
      Polymorphisms in Caspase-7 (CASP7) may modulate the programmed cell death and thus contribute to cervical cancer risk. In this case-control study of 1,486 cervical cancer cases and 1,301 controls, we investigated associations ...
    • Characterization of the standard and recommended CODIS markers. 

      Katsanis, Sara H; Wagner, Jennifer K (Journal of forensic sciences, 2013-01)
      As U.S. courts grapple with constitutional challenges to DNA identification applications, judges are resting legal decisions on the fingerprint analogy, questioning whether the information from a DNA profile could, in light ...
    • Depression in pregnancy, infant birth weight and DNA methylation of imprint regulatory elements. 

      Liu, Y; Murphy, SK; Murtha, AP; Fuemmeler, BF; Schildkraut, J; Huang, Z; Overcash, F; ... (12 authors) (Epigenetics : official journal of the DNA Methylation Society, 2012-07)
      Depressed mood in pregnancy has been linked to low birth weight (LBW, 4,500 g) infants had 5.9% higher methylation at the PLAGL1 DMR compared with normal birth weight infants. Our findings confirm that severe maternal depressed ...
    • Evolution of the sex-related locus and genomic features shared in microsporidia and fungi. 

      Lee, Soo Chan; Corradi, Nicolas; Doan, Sylvia; Dietrich, Fred S; Keeling, Patrick J; Heitman, Joseph (PLoS One, 2010-05-07)
      BACKGROUND: Microsporidia are obligate intracellular, eukaryotic pathogens that infect a wide range of animals from nematodes to humans, and in some cases, protists. The preponderance of evidence as to the origin of the ...
    • Functional annotation signatures of disease susceptibility loci improve SNP association analysis. 

      Iversen, ES; Lipton, G; Clyde, MA; Monteiro, ANA (BMC Genomics, 2014-05-24)
      BACKGROUND: Genetic association studies are conducted to discover genetic loci that contribute to an inherited trait, identify the variants behind these associations and ascertain their functional role in determining the ...
    • Genome-wide association study of acute kidney injury after coronary bypass graft surgery identifies susceptibility loci. 

      Stafford-Smith, Mark; Li, Yi-Ju; Mathew, Joseph P; Li, Yen-Wei; Ji, Yunqi; Phillips-Bute, Barbara G; Milano, Carmelo A; ... (13 authors) (Kidney Int, 2015-10)
      Acute kidney injury (AKI) is a common, serious complication of cardiac surgery. Since prior studies have supported a genetic basis for postoperative AKI, we conducted a genome-wide association study (GWAS) for AKI following ...
    • Genome-wide linkage analysis for human longevity: Genetics of Healthy Aging Study. 

      Beekman, Marian; Blanché, Hélène; Perola, Markus; Hervonen, Anti; Bezrukov, Vladyslav; Sikora, Ewa; Flachsbart, Friederike; ... (41 authors) (Aging Cell, 2013-04)
      Clear evidence exists for heritability of human longevity, and much interest is focused on identifying genes associated with longer lives. To identify such longevity alleles, we performed the largest genome-wide linkage ...
    • Mutation accumulation may be a minor force in shaping life history traits. 

      Dańko, Maciej Jan; Kozłowski, Jan; Vaupel, James Walton; Baudisch, Annette (PLoS One, 2012)
      Is senescence the adaptive result of tradeoffs between younger and older ages or the nonadaptive burden of deleterious mutations that act at older ages? To shed new light on this unresolved question we combine adaptive and ...
    • Novel loci and pathways significantly associated with longevity. 

      Zeng, Yi; Nie, Chao; Min, Junxia; Liu, Xiaomin; Li, Mengmeng; Chen, Huashuai; Xu, Hanshi; ... (57 authors) (Sci Rep, 2016-02-25)
      Only two genome-wide significant loci associated with longevity have been identified so far, probably because of insufficient sample sizes of centenarians, whose genomes may harbor genetic variants associated with health ...
    • rbcL and matK earn two thumbs up as the core DNA barcode for ferns. 

      Li, F; Kuo, L; Rothfels, CJ; Ebihara, A; Chiou, W; Windham, MD; Pryer, KM (PloS one, 2011-01)
      BACKGROUND: DNA barcoding will revolutionize our understanding of fern ecology, most especially because the accurate identification of the independent but cryptic gametophyte phase of the fern's life history--an endeavor ...
    • The evolutionary history of ferns inferred from 25 low-copy nuclear genes. 

      Rothfels, CJ; Li, F; Sigel, EM; Huiet, L; Larsson, A; Burge, DO; Ruhsam, M; ... (10 authors) (Am J Bot, 2015-07)
      UNLABELLED: • PREMISE OF THE STUDY: Understanding fern (monilophyte) phylogeny and its evolutionary timescale is critical for broad investigations of the evolution of land plants, and for providing the point of comparison ...
    • The genomic consequences of adaptive divergence and reproductive isolation between species of manakins. 

      Parchman, TL; Gompert, Z; Braun, MJ; Brumfield, RT; McDonald, DB; Uy, JAC; Zhang, G; ... (10 authors) (Mol Ecol, 2013-06)
      The processes of adaptation and speciation are expected to shape genomic variation within and between diverging species. Here we analyze genomic heterogeneity of genetic differentiation and introgression in a hybrid zone ...
    • The Physarum polycephalum Genome Reveals Extensive Use of Prokaryotic Two-Component and Metazoan-Type Tyrosine Kinase Signaling. 

      Schaap, Pauline; Barrantes, Israel; Minx, Pat; Sasaki, Narie; Anderson, Roger W; Bénard, Marianne; Biggar, Kyle K; ... (38 authors) (Genome Biol Evol, 2015-11-27)
      Physarum polycephalum is a well-studied microbial eukaryote with unique experimental attributes relative to other experimental model organisms. It has a sophisticated life cycle with several distinct stages including amoebal, ...