Browsing by Subject "Genetics"
Now showing items 1-20 of 275
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A Genome-Wide RNAi Screen Identifies CDC-42 and GDI-1 as In Vivo Regulators of Invadopodia
(2015)Basement membrane (BM) is a sheet-like extracellular matrix that underlies most tissues and acts as a barrier to invading cells. Many cell types, including immune cells, cells migrating during development and morphogenesis, ... -
A Genomic Definition of Centromeres in Complex Genomes
(2011)Centromeres, or sites of chromosomal spindle attachment during mitosis and meiosis, are non-randomly distributed in complex genomes and are largely associated with expansive, near-identical satellite DNA arrays. While the ... -
A Preliminary Study of Threonine Deaminase Duplication in Solanaceae
(2013)One of the most important questions in evolutionary biology is how new genes and new functions arise and evolve. Among the theories addressing this question, gene duplication is one of the most popular. Previous study has ... -
Acute and Intergenerational Nutrient Responses in Caenorhabditis elegans
(2017)Nearly all animals live in environments with fluctuations in nutrient availability. The ability to sense and respond to these changes is essential for survival. Nutrition impacts physiology immediately, but can also have ... -
An evolutionary genomics approach towards understanding Plasmodium vivax in central Africa
(2022)Increased attention has recently been placed on understanding the natural variation of the malaria parasite Plasmodium vivax across the globe, as in 2020 alone, P. vivax caused an estimated 4.5 million malaria cases and ... -
Ancestry-based Methods for Characterizing the Evolutionary History of Admixed Populations
(2022)Admixture occurs when previously isolated populations come together to form a new population with genetic ancestry from those sources. Admixture is ubiquitous across the tree of life, including humans, and is often associated ... -
B-cyclin/CDK Regulation of Mitotic Spindle Assembly through Phosphorylation of Kinesin-5 Motors in the Budding Yeast, <italic>Saccharomyces cerevisiae</italic>
(2012)Although it has been known for many years that B-cyclin/CDK complexes regulate the assembly of the mitotic spindle and entry into mitosis, the full complement of relevant CDK targets has not been identified. It has previously ... -
Basement Membrane Dynamics During Anchor Cell Invasion
(2015)Basement membranes are a dense, sheet-like form of extracellular matrix that underlie epithelia and endothelia, and surround muscle, fat and Schwann cells. Basement membranes separate tissues and protect them from mechanical ... -
Bayesian Kernel Models for Statistical Genetics and Cancer Genomics
(2017)The main contribution of this thesis is to examine the utility of kernel regression ap- proaches and variance component models for solving complex problems in statistical genetics and molecular biology. Many of these types ... -
Bayesian modeling of microbial physiology
(2017)Microbial population growth measurements are widespread in the study of microorganisms, providing insight into areas including genetics, physiology, and engineering. The most common models of microbial population growth ... -
Birth cohort differences in the prevalence of longevity-associated variants in APOE and FOXO3A in Danish long-lived individuals.
(Exp Gerontol, 2014-09)Gene variants found to associate with human longevity in one population rarely replicate in other populations. The lack of consistent findings may partly be explained by genetic heterogeneity among long-lived individuals ... -
Causes and Consequences of Recombination Rate Variation
(2014)Recombination is the process in which genetic material is exchanged between one's homologous chromosome pairs during egg or sperm development (meiosis). Recombination is necessary for proper segregation of chromosomes during ... -
Causes and Consequences of Recombination Rate Variation in Drosophila
(2011)Recombination occurs during meiosis to produce new allelic combinations in natural populations, and thus strongly affects evolutionary processes. The model system Drosophila has been crucial for understanding the mechanics ... -
Cell Fate Specification and the Regulation of RNA-dependent DNA Methylation in the Arabidopsis Root Meristem
(2016)The Arabidopsis root apical meristem (RAM) is a complex tissue capable of generating all the cell types that ultimately make up the root. The work presented in this thesis takes advantage of the versatility of high-throughput ... -
Cellular Coordinators: Mechanisms by Which Non-Enzymatic Proteins Contribute to Growth and Cell Surface Remodeling in the Human Fungal Pathogen Cryptococcus neoformans
(2022)My thesis work has focused on characterizing mechanisms by which human fungal pathogens regulate their adaptive cellular responses in order to survive and cause disease in the human host. Unlike most microbial fungi found ... -
Cerebral Cavernous Malformations: From Two-Hit Mechanism to Developing a Targeted Therapy
(2013)Cerebral cavernous malformations (CCMs) are multicavernous vascular lesions affecting the central nervous system. Affected individuals have a lifetime risk of recurrent headaches, focal neurological deficits, seizures, ... -
Characterization of Vomeronasal Type-1 Receptor (V1R) Repertoire Diversity in Mouse Lemurs (Genus Microcebus)
(2013)An organism's ability to detect and interpret chemical signals from the surrounding environment is vital to its survival. In mammals, the vomeronasal organ provides an integral part of this requirement as it allows for the ... -
Characterizing Genetic Drivers of Lymphoma through High-Throughput Sequencing
(2016)The advent of next-generation sequencing, now nearing a decade in age, has enabled, among other capabilities, measurement of genome-wide sequence features at unprecedented scale and resolution. In this dissertation, I describe ... -
Characterizing the Relationship Between Cell-Cycle Progression and a Transcriptional Oscillator
(2013)The cell division cycle is the process in which the entirety of a cell's contents is duplicated completely and then equally segregated into two identical daughter cells. The order of the steps in the cell cycle must be followed ...
