Now showing items 1-3 of 3

    • Acute administration of unacylated ghrelin has no effect on Basal or stimulated insulin secretion in healthy humans. 

      Tong, Jenny; Davis, Harold W; Summer, Suzanne; Benoit, Stephen C; Haque, Ahrar; Bidlingmaier, Martin; Tschöp, Matthias H; ... (8 authors) (Diabetes, 2014-07)
      Unacylated ghrelin (UAG) is the predominant ghrelin isoform in the circulation. Despite its inability to activate the classical ghrelin receptor, preclinical studies suggest that UAG may promote β-cell function. We hypothesized ...
    • Ghrelin suppresses glucose-stimulated insulin secretion and deteriorates glucose tolerance in healthy humans. 

      Tong, Jenny; Prigeon, Ronald L; Davis, Harold W; Bidlingmaier, Martin; Kahn, Steven E; Cummings, David E; Tschöp, Matthias H; ... (8 authors) (Diabetes, 2010-09)
      OBJECTIVE: The orexigenic gut hormone ghrelin and its receptor are present in pancreatic islets. Although ghrelin reduces insulin secretion in rodents, its effect on insulin secretion in humans has not been established. ...
    • Ghrelin. 

      Müller, TD; Nogueiras, R; Andermann, ML; Andrews, ZB; Anker, SD; Argente, J; Batterham, RL; ... (57 authors) (Mol Metab, 2015-06)
      BACKGROUND: The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence supports more complicated and nuanced roles for the ...