Now showing items 1-3 of 3

    • CLARITY and PACT-based imaging of adult zebrafish and mouse for whole-animal analysis of infections. 

      Cronan, MR; Jurcic Smith, KL; Lee, S; Oehlers, SH; Rosenberg, AF; Saelens, Joseph W; Sisk, DM; ... (8 authors) (Dis Model Mech, 2015-12)
      Visualization of infection and the associated host response has been challenging in adult vertebrates. Owing to their transparency, zebrafish larvae have been used to directly observe infection in vivo; however, such larvae ...
    • Interception of host angiogenic signalling limits mycobacterial growth. 

      Oehlers, SH; Cronan, MR; Scott, NR; Thomas, MI; Okuda, KS; Walton, EM; Beerman, RW; ... (9 authors) (Nature, 2015-01-29)
      Pathogenic mycobacteria induce the formation of complex cellular aggregates called granulomas that are the hallmark of tuberculosis. Here we examine the development and consequences of vascularization of the tuberculous ...
    • Lysosomal Disorders Drive Susceptibility to Tuberculosis by Compromising Macrophage Migration. 

      Berg, RD; Levitte, S; O'Sullivan, MP; O'Leary, SM; Cambier, CJ; Cameron, J; Takaki, KK; ... (11 authors) (Cell, 2016-03-24)
      A zebrafish genetic screen for determinants of susceptibility to Mycobacterium marinum identified a hypersusceptible mutant deficient in lysosomal cysteine cathepsins that manifests hallmarks of human lysosomal storage diseases. ...