Browsing by Subject "HDAC"
Now showing items 1-5 of 5
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Design, Synthesis, and Biological Characterization of Largazole Analogues
(2016)Histone deacetylases (HDACs) have been shown to play key roles in tumorigenesis, andhave been validated as effective enzyme target for cancer treatment. Largazole, a marine naturalproduct isolated from the cyanobacterium ... -
I. Formal Synthesis of SCH 351448. II. Synthesis and Characterization of Largazole Analogues.
(2012)Part I: Extensive studies for treating hypercholesterolemia, one of the major causes of human morbidity throughout the world, have led to the development of statin drugs-the most prevalent drug prescribed today. In addition ... -
MEF2 and the Right Ventricle: From Development to Disease.
(Frontiers in cardiovascular medicine, 2019-01)Pulmonary arterial hypertension is a progressive and ultimately life-limiting disease in which survival is closely linked to right ventricular function. The right ventricle remains relatively understudied, as it is known ... -
Roles of Cytoplasmic Deacetylase Hdac6 in Oncogenic Tumorigenesis
(2008-04-21)Reversible acetylation has emerged as an important post-translational modification that rivals phosphorylation in regulating chromatin structure and gene expression. Acetylation of histone is associated with transcriptional ... -
Targeting Histone Deacetylases in Advanced Prostate Cancer
(2015)The androgen receptor (AR) signaling axis is a well-established therapeutic target in prostate cancer, due to its central role in tumor maintenance and progression. Although patients respond initially to androgen deprivation ...
