Now showing items 1-5 of 5

    • Design, Synthesis, and Biological Characterization of Largazole Analogues 

      Kim, Bumki (2016)
      Histone deacetylases (HDACs) have been shown to play key roles in tumorigenesis, andhave been validated as effective enzyme target for cancer treatment. Largazole, a marine naturalproduct isolated from the cyanobacterium ...
    • I. Formal Synthesis of SCH 351448. II. Synthesis and Characterization of Largazole Analogues. 

      Park, Heekwang (2012)
      Part I: Extensive studies for treating hypercholesterolemia, one of the major causes of human morbidity throughout the world, have led to the development of statin drugs-the most prevalent drug prescribed today. In addition ...
    • MEF2 and the Right Ventricle: From Development to Disease. 

      Clapham, Katharine R; Singh, Inderjit; Capuano, Isabella S; Rajagopal, Sudarshan; Chun, Hyung J (Frontiers in cardiovascular medicine, 2019-01)
      Pulmonary arterial hypertension is a progressive and ultimately life-limiting disease in which survival is closely linked to right ventricular function. The right ventricle remains relatively understudied, as it is known ...
    • Roles of Cytoplasmic Deacetylase Hdac6 in Oncogenic Tumorigenesis 

      Lee, Yishan (2008-04-21)
      Reversible acetylation has emerged as an important post-translational modification that rivals phosphorylation in regulating chromatin structure and gene expression. Acetylation of histone is associated with transcriptional ...
    • Targeting Histone Deacetylases in Advanced Prostate Cancer 

      Brunner, Abigail Maria (2015)
      The androgen receptor (AR) signaling axis is a well-established therapeutic target in prostate cancer, due to its central role in tumor maintenance and progression. Although patients respond initially to androgen deprivation ...