Browsing by Subject "Health Sciences, Immunology"
Now showing items 1-16 of 16
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Cryptococcus Neoformans Interactions with Surfactant Proteins: Implications for Innate Pulmonary Immunity
(2009)Concurrent with the global escalation of the AIDS pandemic, cryptococcal infections are increasing and are of significant medical importance. Although improvements in antifungal therapy have advanced the treatment ... -
Interactions of Mast Cells with the Lymphatic System: Delivery of Peripheral Signals to Lymph Nodes by Mast Cell-Derived Particles
(2009)Mast cells, best known for their pathologic role in allergy, have recently been shown to have key roles in the initiation of adaptive immune responses. These cells are located throughout the body just beneath barriers separating ... -
Leptin Regulation of Thymopoiesis During Endotoxin-Induced Acute Thymic Atrophy
(2009)Thymus atrophy is highly inducible by stress and prolonged thymus atrophy can contribute to T cell deficiency or inhibit immune recovery after acute peripheral T cell depletion. Little is known regarding the mechanisms driving ... -
Mechanisms of Molecular Chaperone Surface Binding and Endocytosis: Insights into the Molecular Basis for GRP94 Immune Function
(2010)Extracellular GRP94 can elicit both innate and adaptive immune responses by interacting with endocytic and signaling receptors on professional antigen presenting cells (pAPCs). CD91 was the first receptor proposed to facilitate ... -
Mechanistic and Genetic Biases in Human Immunoglobulin Heavy Chain Development
(2008-04-23)Broadly neutralizing antibodies against HIV are rare; most patients never develop them at detectable levels. The discovery of four such antibodies therefore warrants research into their origins and their presumed unique ... -
Receptor-Mediated Antigen Delivery by Α<Sub>2</Sub>-Macroglobulin: Effect on Cytotoxic T Lymphocyte Immunity and Implications for Vaccine Development
(2009)<p>The receptor-recognized form of α2-macroglobulin (α2M*) targets antigens (Ag) to professional Ag-presenting cells (APCs) for rapid internalization, processing, and presentation. When employed as an Ag delivery ... -
Regulating Emergency Granulopoiesis
(2010)Normally, neutrophil pools are maintained by "steady-state" granulopoiesis. Infections and inflammation, however, trigger neutrophilias that are supported by a hematopoietic program of accelerated granulopoiesis known as ... -
Role of E-proteins in B Lymphocyte Commitment and Thymocyte Selection
(2009)The E-protein transcription factors E2A and HEB regulate various cell processes during the development of B and T lymphocytes, including cell differentiation, lineage commitment, recombination of immune receptor ... -
The Function of LAT in T Cell Activation and Autoimmunity
(2010)LAT (linker for activation of T cells) is an important transmembrane adaptor protein in TCR-mediated signaling. Upon TCR engagement, LAT associates with multiple proteins which allows for the activation of downstream signaling ... -
The Influence of B-cell Tolerance on Humoral Immunity to HIV-1
(2010)Several HIV-1 neutralizing antibodies (e.g. 2F5, 4E10) have been shown to react with self-antigens, suggesting that effective humoral responses to HIV-1 may be constrained by the tolerization of HIV-reactive B cells that ... -
The Innate Immune Response to Vaccinia Viral Infection
(2010)Vaccinia virus (VV) is the most thoroughly studied member of the Poxviridae family and the vaccine used to achieve the only successful eradication of a human disease. Over the years, it has proven itself as a useful tool ... -
The Role of CD4+ T cells in the CD8+ T cell Response to Vaccinia Viral Infection
(2010)The role of CD4 T cell help in primary and secondary CD8 T cell responses to infectious pathogens remains incompletely defined. The primary CD8 T response to infections was initially thought to be largely independent of ... -
The Role of Glucose Metabolism in T Cell Stimulation and Homeostasis
(2009)The role of two cell extrinsic signals, T cell receptor (TCR) ligation and interleukin-7, in promoting glucose uptake and survival of T lymphocytes is examined in this work. Both of these signals are capable of regulating ... -
The Role of Nuclear Position and Locus Conformation in Regulating V(D)J Recombination of the Tcrb Locus
(2008-12-12)Recombination of Tcrb gene segments in DN thymocytes is subject to allelic exclusion, such that only a single functional Vβ - DJβ rearrangement is generated per T cell. For Tcrb to be allelically excluded the two alleles ... -
Toll like Receptor 4-Mediated Immune Responses in the Bladder Epithelium
(2008-12-08)The urinary tract is one of the most intractable mucosal surfaces for pathogens to colonize. In addition to the natural barriers at this site, potential pathogens have to contend with the vigorous local innate immune response ... -
Using Genome-wide Approaches to Characterize the Relationship Between Genomic Variation and Disease: A Case Study in Oligodendroglioma and Staphylococcus arueus
(2010)Genetic variation is a natural occurrence in the genome that contributes to the phenotypic differences observed between individuals as well as the phenotypic outcomes of various diseases, including infectious disease and ...
