Browsing by Subject "Health Sciences, Oncology"
Now showing items 1-11 of 11
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Akt, Glucose Metabolism, and the Bcl-2 Family
(2010)Normal cells require input from extrinsic growth factors to control proliferation and survival. Recent studies have demonstrated that these same extrinsic signals also regulate cellular metabolism to ensure that metabolism ... -
Characterization and Modeling of Fluctuating Hypoxia in Breast Cancer
(2008-08-08)Tumor hypoxia is an enduring problem for traditional cancer therapies such as radiation and chemotherapy. This obstacle has traditionally been attributed to the widespread presence of chronic, diffusion-limited hypoxia ... -
Clinical Implementation of a Real-Time Electromagnetic Localization System: Accuracy, Motion and Margin Analysis for IMRT and IMAT Treatments
(2010)Accurate delivery of external beam radiation therapy relies on localization of the treatment target. For this work, the accuracy of an electromagnetic localization system (ELS) was first verified. Next, prostate deformations ... -
Correlation Imaging for Improved Cancer Detection
(2008-11-10)We present a new x-ray imaging technique, Correlation Imaging (CI), for improved breast and lung cancer detection. In CI, multiple low-dose radiographic images are acquired along a limited angular arc. Information ... -
Drug Delivery and Anti-Vascular Effects of Temperature Sensitive Liposomal Doxorubicin
(2010)Traditionally, the goal of nanoparticle-based chemotherapy has been to decrease normal tissue toxicity by improving drug specificity to tumor. Relying on the EPR effect (Enhanced Permeability and Retention), a host ... -
Evaluation of Volumetric Losses During Radiation Therapy Using Image Guidance of Electronic Portal Imaging Device
(2010)<bold>Purpose:</bold> Changes in patient volume, due to tumor shrinkage, dehydration, dysphagia and atrophy, could present issues in the accuracy of dosimetry throughout the course of treatment. The aim of this work is to ... -
Metabolic Targeting of Cancer Cells: Two Molecular Mechanisms Involving Glucose Metabolism
(2009)Selective therapeutic targeting of tumors requires identification of differences between the homeostatic requirements of cancer and host cells. One such difference is the manner in which cancer cells acquire energy. Cancer ... -
On-board Single Photon Emission Computed Tomography (SPECT) for Biological Target Localization
(2010)On-board imaging is useful for guiding radiation to patients in the treatment position; however, current treatment-room imaging modalities are not sensitive to physiology - features that may differentiate tumor from nearby ... -
The Role of Glucose Metabolism in T Cell Stimulation and Homeostasis
(2009)The role of two cell extrinsic signals, T cell receptor (TCR) ligation and interleukin-7, in promoting glucose uptake and survival of T lymphocytes is examined in this work. Both of these signals are capable of regulating ... -
The Role of the Myelin and Lymphocyte Protein (MAL) in Breast and Ovarian Cancer
(2010)MAL (myelin and lymphocyte protein), has been implicated in several malignancies including esophageal, gastric, and cervical cancers. We have demonstrated that the MAL protein is expressed in the normal breast epithelium, ... -
The Roles of Rap1 in Cancer Metastasis and Pancreatic Islet Beta Cell Function
(2009)Signaling from the G protein, Rap1 is involved in several fundamental biological processes. Yet the mechanism or even consequence of Rap1 signaling in several biologies and diseases is still unclear. Rap1 has been implicated ...
