Browsing by Subject "Heart"
Now showing items 1-20 of 25
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A comprehensive guide to genetic variants and post-translational modifications of cardiac troponin C.
(Journal of muscle research and cell motility, 2020-11-11)Familial cardiomyopathy is an inherited disease that affects the structure and function of heart muscle and has an extreme range of phenotypes. Among the millions of affected individuals, patients with hypertrophic (HCM), ... -
A dual role for ErbB2 signaling in cardiac trabeculation.
(Development, 2010-11)Cardiac trabeculation is a crucial morphogenetic process by which clusters of ventricular cardiomyocytes extrude and expand into the cardiac jelly to form sheet-like projections. Although it has been suggested that cardiac ... -
An isolated working heart system for large animal models.
(J Vis Exp, 2014-06-11)Since its introduction in the late 19(th) century, the Langendorff isolated heart perfusion apparatus, and the subsequent development of the working heart model, have been invaluable tools for studying cardiovascular function ... -
An off-the-shelf artificial cardiac patch improves cardiac repair after myocardial infarction in rats and pigs.
(Science translational medicine, 2020-04)Cell therapy has been a promising strategy for cardiac repair after injury or infarction; however, low retention and engraftment of transplanted cells limit potential therapeutic efficacy. Seeding scaffold material with ... -
Arterial pole progenitors interpret opposing FGF/BMP signals to proliferate or differentiate.
(Development, 2010-09)During heart development, a subpopulation of cells in the heart field maintains cardiac potential over several days of development and forms the myocardium and smooth muscle of the arterial pole. Using clonal and explant ... -
Assessing cardiac injury in mice with dual energy-microCT, 4D-microCT, and microSPECT imaging after partial heart irradiation.
(Int J Radiat Oncol Biol Phys, 2014-03-01)PURPOSE: To develop a mouse model of cardiac injury after partial heart irradiation (PHI) and to test whether dual energy (DE)-microCT and 4-dimensional (4D)-microCT can be used to assess cardiac injury after PHI to complement ... -
Bbeta-adrenergic receptor kinase-1 levels in catecholamine-induced myocardial hypertrophy: regulation by beta- but not alpha1-adrenergic stimulation.
(Hypertension, 1999-01)Pressure overload ventricular hypertrophy is accompanied by dysfunctional beta-adrenergic receptor signaling due to increased levels of the beta-adrenergic receptor kinase-1, which phosphorylates and desensitizes beta-adrenergic ... -
Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection.
(J Clin Invest, 2007-09)Deleterious effects on the heart from chronic stimulation of beta-adrenergic receptors (betaARs), members of the 7 transmembrane receptor family, have classically been shown to result from Gs-dependent adenylyl ... -
Characterization of Drosophila Ctr1a: New Roles for Ctr1 Proteins and Copper in Physiology and Cell Signaling Pathways
(2008-10-21)Copper is an essential trace element required by all aerobic organisms as a co-factor for enzymes involved in normal growth, development and physiology. Ctr1 proteins are members of a highly conserved family of copper importers ... -
Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes.
(Circ Res, 1999-01-08)-Transgenic mouse models have been developed to manipulate beta-adrenergic receptor (betaAR) signal transduction. Although several of these models have altered betaAR subtypes, the specific functional sequelae of betaAR ... -
Emerging roles of junctophilin-2 in the heart and implications for cardiac diseases.
(Cardiovascular research, 2014-07)Cardiomyocytes rely on a highly specialized subcellular architecture to maintain normal cardiac function. In a little over a decade, junctophilin-2 (JPH2) has become recognized as a cardiac structural protein critical in ... -
Historical Structural Barriers and Cardiovascular Inequities.
(JAMA network open, 2023-07) -
Home is Where the Heart Is: Interstage Home Monitoring in Infants With Single-Ventricle Heart Disease.
(Journal of cardiothoracic and vascular anesthesia, 2021-10) -
Junctophilin-2 at the intersection of arrhythmia and pathologic cardiac remodeling.
(Heart rhythm, 2016-03) -
Junctophilin-2 is necessary for T-tubule maturation during mouse heart development.
(Cardiovascular research, 2013-10)AIMS:Transverse tubules (TTs) provide the basic subcellular structures that facilitate excitation-contraction (EC) coupling, the essential process that underlies normal cardiac contractility. Previous studies have shown ... -
Level of beta-adrenergic receptor kinase 1 inhibition determines degree of cardiac dysfunction after chronic pressure overload-induced heart failure.
(Circulation, 2005-02-08)BACKGROUND: Heart failure is characterized by abnormalities in beta-adrenergic receptor (betaAR) signaling, including increased level of myocardial betaAR kinase 1 (betaARK1). Our previous studies have shown that inhibition ... -
Ligand-induced overexpression of a constitutively active beta2-adrenergic receptor: pharmacological creation of a phenotype in transgenic mice.
(Proc Natl Acad Sci U S A, 1997-01-07)Transgenic overexpression (40- to 100-fold) of the wild-type human beta2-adrenergic receptor in the hearts of mice leads to a marked increase in cardiac contractility, which is apparently due to the low level of spontaneous ... -
Loss of dynamic regulation of G protein-coupled receptor kinase 2 by nitric oxide leads to cardiovascular dysfunction with aging.
(American journal of physiology. Heart and circulatory physiology, 2020-05)Nitric oxide (NO) and S-nitrosothiol (SNO) are considered cardio- and vasoprotective substances. We now understand that one mechanism in which NO/SNOs provide cardiovascular protection is through their direct inhibition ... -
Micro-CT of rodents: state-of-the-art and future perspectives.
(Phys Med, 2014-09)Micron-scale computed tomography (micro-CT) is an essential tool for phenotyping and for elucidating diseases and their therapies. This work is focused on preclinical micro-CT imaging, reviewing relevant principles, technologies, ... -
microRNA-21-5p dysregulation in exosomes derived from heart failure patients impairs regenerative potential.
(The Journal of clinical investigation, 2019-04)Exosomes, as functional paracrine units of therapeutic cells, can partially reproduce the reparative properties of their parental cells. The constitution of exosomes, as well as their biological activity, largely depends ...
