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Browsing by Subject "Hepatitis C"
Now showing items 1-14 of 14
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A cross-sectional analysis of HIV and hepatitis C clinical trials 2007 to 2010: the relationship between industry sponsorship and randomized study design.
(Trials, 2014-01)<h4>Background</h4>The proportion of clinical research sponsored by industry will likely continue to expand as federal funds for academic research decreases, particularly in the fields of HIV/AIDS and hepatitis C (HCV). ... -
A flexible statistical model for alignment of label-free proteomics data--incorporating ion mobility and product ion information.
(BMC Bioinformatics, 2013-12-16)BACKGROUND: The goal of many proteomics experiments is to determine the abundance of proteins in biological samples, and the variation thereof in various physiological conditions. High-throughput quantitative proteomics, ... -
A minimal monitoring approach for the treatment of hepatitis C virus infection (ACTG A5360 [MINMON]): a phase 4, open-label, single-arm trial.
(The lancet. Gastroenterology & hepatology, 2022-04)<h4>Background</h4>Despite widespread availability of direct-acting antivirals including generic formulations, limited progress has been made in the global adoption of hepatitis C virus (HCV) treatment. Barriers to treatment ... -
A Systematic Review of Race and Ethnicity in Hepatitis C Clinical Trial Enrollment.
(J Natl Med Assoc, 2016-02)The African American/Black population in the United States (US) is disproportionately affected by hepatitis C virus (HCV) and has lower response rates to current treatments. This analysis evaluates the participation of African ... -
Adoption of direct-acting antiviral medications for hepatitis C: a retrospective observational study.
(BMC health services research, 2019-07-25)<h4>Background</h4>Approximately 3.5 million Americans are infected with the hepatitis C virus (HCV). Although many patients with HCV are asymptomatic, HCV is the leading cause of infection-related death in the U.S. With ... -
Community-based HCV screening: knowledge and attitudes in a high risk urban population.
(BMC Infect Dis, 2014-02-10)BACKGROUND: In an attempt to curtail the rising morbidity and mortality from undiagnosed HCV (hepatitis C virus) in the United States, screening guidelines have been expanded to high-risk individuals and persons born 1945-1965. ... -
Detection and Characterization of Human Pegivirus 2, Vietnam.
(Emerging infectious diseases, 2018-11)We report human pegivirus 2 (HPgV-2) infection in Vietnam. We detected HPgV-2 in some patients with hepatitis C virus/HIV co-infection but not in patients with HIV or hepatitis A, B, or C virus infection, nor in healthy ... -
Elucidation of hepatitis C virus transmission and early diversification by single genome sequencing.
(PLoS Pathog, 2012)A precise molecular identification of transmitted hepatitis C virus (HCV) genomes could illuminate key aspects of transmission biology, immunopathogenesis and natural history. We used single genome sequencing of 2,922 half ... -
Functional Evaluation of Causal Mutations Identified in Human Genetic Studies
(2016)Human genetics has been experiencing a wave of genetic discoveries thanks to the development of several technologies, such as genome-wide association studies (GWAS), whole-exome sequencing, and whole genome sequencing. Despite ... -
Meningococcemia in a patient coinfected with hepatitis C virus and HIV.
(Emerg Infect Dis, 2000-11)We describe the first reported case of meningococcemia in a patient coinfected with hepatitis C virus and HIV. Hypocomplementemia secondary to hepatic dysfunction may have enhanced the patient's susceptibility to meningococcal ... -
Successes and Challenges on the Road to Cure Hepatitis C.
(PLoS Pathog, 2015-06) -
Survey of methadone-drug interactions among patients of methadone maintenance treatment program in Taiwan.
(Subst Abuse Treat Prev Policy, 2012-03-20)BACKGROUND: Although methadone has been used for the maintenance treatment of opioid dependence for decades, it was not introduced in China or Taiwan until 2000s. Methadone-drug interactions (MDIs) have been shown to cause ... -
Testing and Clinical Management of Health Care Personnel Potentially Exposed to Hepatitis C Virus - CDC Guidance, United States, 2020.
(MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports, 2020-07)Exposure to hepatitis viruses is a recognized occupational risk for health care personnel (HCP). This report establishes new CDC guidance that includes recommendations for a testing algorithm and clinical management for ... -
The increasing impact of human immunodeficiency virus infections, sexually transmitted diseases, and viral hepatitis in Durham County, North Carolina: a call for coordinated and integrated services.
(N C Med J, 2011-11)BACKGROUND: Durham County, North Carolina, faces high rates of human immunodeficiency virus (HIV) infection (with or without progression to AIDS) and sexually transmitted diseases (STDs). We explored the use of health care ...
