Browsing by Subject "Hippocampus"
Now showing items 1-20 of 22
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A Peptide Uncoupling BDNF Receptor TrkB from Phospholipase Cγ1 Prevents Epilepsy Induced by Status Epilepticus.
(Neuron, 2015-11-04)The BDNF receptor tyrosine kinase, TrkB, underlies nervous system function in both health and disease. Excessive activation of TrkB caused by status epilepticus promotes development of temporal lobe epilepsy (TLE), revealing ... -
Age-related effects on the neural correlates of autobiographical memory retrieval.
(Neurobiol Aging, 2012-07)Older adults recall less episodically rich autobiographical memories (AM), however, the neural basis of this effect is not clear. Using functional MRI, we examined the effects of age during search and elaboration phases ... -
Amygdala volume changes in posttraumatic stress disorder in a large case-controlled veterans group.
(Arch Gen Psychiatry, 2012-11)CONTEXT: Smaller hippocampal volumes are well established in posttraumatic stress disorder (PTSD), but the relatively few studies of amygdala volume in PTSD have produced equivocal results. OBJECTIVE: To assess a large cohort ... -
Amygdala, Hippocampus, and Ventral Medial Prefrontal Cortex Volumes Differ in Maltreated Youth with and without Chronic Posttraumatic Stress Disorder.
(Neuropsychopharmacology, 2016-02)Posttraumatic stress disorder (PTSD) is considered a disorder of recovery where individuals fail to learn and retain extinction of the traumatic fear response. In maltreated youth, PTSD is common, chronic, and associated ... -
Brain activity during episodic retrieval of autobiographical and laboratory events: an fMRI study using a novel photo paradigm.
(J Cogn Neurosci, 2004-11)Functional neuroimaging studies of episodic memory retrieval generally measure brain activity while participants remember items encountered in the laboratory ("controlled laboratory condition") or events from their own life ... -
Co-activation of the amygdala, hippocampus and inferior frontal gyrus during autobiographical memory retrieval.
(Neuropsychologia, 2005)Functional MRI was used to investigate the role of medial temporal lobe and inferior frontal lobe regions in autobiographical recall. Prior to scanning, participants generated cue words for 50 autobiographical memories and ... -
Contributions of Dorsal/Ventral Hippocampus and Dorsolateral/Dorsomedial Striatum to Interval Timing
(2016)Humans and animals have remarkable capabilities in keeping time and using time as a guide to orient their learning and decision making. Psychophysical models of timing and time perception have been proposed for decades and ... -
Deferoxamine regulates neuroinflammation and iron homeostasis in a mouse model of postoperative cognitive dysfunction.
(J Neuroinflammation, 2016-10-12)BACKGROUND: Postoperative cognitive dysfunction (POCD) is a common complication after surgery, especially amongst elderly patients. Neuroinflammation and iron homeostasis are key hallmarks of several neurological disorders. ... -
Demographic, maltreatment, and neurobiological correlates of PTSD symptoms in children and adolescents.
(J Pediatr Psychol, 2010-06)OBJECTIVE: To examine the relationships of demographic, maltreatment, neurostructural and neuropsychological measures with total posttraumatic stress disorder (PTSD) symptoms. METHODS: Participants included 216 children ... -
Dosimetric analysis of the alopecia preventing effect of hippocampus sparing whole brain radiation therapy.
(Radiat Oncol, 2015-11-26)BACKGROUND: Whole brain radiation therapy (WBRT) is widely used for the treatment of brain metastases. Cognitive decline and alopecia are recognized adverse effects of WBRT. Recently hippocampus sparing whole brain radiation ... -
Event memory: A theory of memory for laboratory, autobiographical, and fictional events.
(Psychol Rev, 2015-01)An event memory is a mental construction of a scene recalled as a single occurrence. It therefore requires the hippocampus and ventral visual stream needed for all scene construction. The construction need not come with ... -
Functional neuroimaging of autobiographical memory.
(Trends Cogn Sci, 2007-05)Functional neuroimaging studies of autobiographical memory have grown dramatically in recent years. These studies are important because they can investigate the neural correlates of processes that are difficult to study ... -
Hippocampus shape analysis and late-life depression.
(PLoS One, 2008-03-19)Major depression in the elderly is associated with brain structural changes and vascular lesions. Changes in the subcortical regions of the limbic system have also been noted. Studies examining hippocampus volumetric differences ... -
Imagery and retrieval of auditory and visual information: neural correlates of successful and unsuccessful performance.
(Neuropsychologia, 2011-06)Remembering past events - or episodic retrieval - consists of several components. There is evidence that mental imagery plays an important role in retrieval and that the brain regions supporting imagery overlap with those ... -
Induction of hippocampal long-term potentiation during waking leads to increased extrahippocampal zif-268 expression during ensuing rapid-eye-movement sleep.
(J Neurosci, 2002-12-15)Rapid-eye-movement (REM) sleep plays a key role in the consolidation of memories acquired during waking (WK). The search for mechanisms underlying that role has revealed significant correlations in the patterns of neuronal ... -
Mechanism of neuroprotective mitochondrial remodeling by PKA/AKAP1.
(PLoS Biol, 2011-04)Mitochondrial shape is determined by fission and fusion reactions catalyzed by large GTPases of the dynamin family, mutation of which can cause neurological dysfunction. While fission-inducing protein phosphatases have been ... -
Memory capacity of networks with stochastic binary synapses.
(PLoS Comput Biol, 2014-08)In standard attractor neural network models, specific patterns of activity are stored in the synaptic matrix, so that they become fixed point attractors of the network dynamics. The storage capacity of such networks has ... -
Memory maintenance in synapses with calcium-based plasticity in the presence of background activity.
(PLoS Comput Biol, 2014-10)Most models of learning and memory assume that memories are maintained in neuronal circuits by persistent synaptic modifications induced by specific patterns of pre- and postsynaptic activity. For this scenario to be viable, ... -
Reduced hippocampal and amygdala activity predicts memory distortions for trauma reminders in combat-related PTSD.
(J Psychiatr Res, 2011-05)Neurobiological models of posttraumatic stress disorder (PTSD) suggest that altered activity in the medial temporal lobes (MTL) during encoding of traumatic memories contribute to the development and maintenance of the disorder. ... -
Sequential ionic and conformational signaling by calcium channels drives neuronal gene expression.
(Science, 2016-02-19)Voltage-gated CaV1.2 channels (L-type calcium channel α1C subunits) are critical mediators of transcription-dependent neural plasticity. Whether these channels signal via the influx of calcium ion (Ca(2+)), voltage-dependent ...
