Now showing items 1-14 of 14

    • A noisy linear map underlies oscillations in cell size and gene expression in bacteria. 

      Tanouchi, Yu; Pai, Anand; Park, Heungwon; Huang, Shuqiang; Stamatov, Rumen; Buchler, Nicolas E; You, Lingchong (Nature, 2015-07-16)
      During bacterial growth, a cell approximately doubles in size before division, after which it splits into two daughter cells. This process is subjected to the inherent perturbations of cellular noise and thus requires regulation ...
    • A plant genetic network for preventing dysbiosis in the phyllosphere. 

      Chen, Tao; Nomura, Kinya; Wang, Xiaolin; Sohrabi, Reza; Xu, Jin; Yao, Lingya; Paasch, Bradley C; ... (15 authors) (Nature, 2020-04-08)
      The aboveground parts of terrestrial plants, collectively called the phyllosphere, have a key role in the global balance of atmospheric carbon dioxide and oxygen. The phyllosphere represents one of the most abundant habitats ...
    • Airway basal stem cells: a perspective on their roles in epithelial homeostasis and remodeling. 

      Rock, Jason R; Randell, Scott H; Hogan, Brigid LM (Dis Model Mech, 2010-09)
      The small airways of the human lung undergo pathological changes in pulmonary disorders, such as chronic obstructive pulmonary disease (COPD), asthma, bronchiolitis obliterans and cystic fibrosis. These clinical problems ...
    • Copper signaling axis as a target for prostate cancer therapeutics. 

      Safi, Rachid; Nelson, Erik R; Chitneni, Satish K; Franz, Katherine J; George, Daniel J; Zalutsky, Michael R; McDonnell, Donald P (Cancer Res, 2014-10-15)
      Previously published reports indicate that serum copper levels are elevated in patients with prostate cancer and that increased copper uptake can be used as a means to image prostate tumors. It is unclear, however, to what ...
    • Deficiency of α-1-antitrypsin influences systemic iron homeostasis. 

      Ghio, Andrew J; Soukup, Joleen M; Richards, Judy H; Fischer, Bernard M; Voynow, Judith A; Schmechel, Donald E (Int J Chron Obstruct Pulmon Dis, 2013)
      There is evidence that proteases and antiproteases participate in the iron homeostasis of cells and living systems. We tested the postulate that α-1 antitrypsin (A1AT) polymorphism and the consequent deficiency ...
    • Genome-wide direct target analysis reveals a role for SHORT-ROOT in root vascular patterning through cytokinin homeostasis. 

      Cui, Hongchang; Hao, Yueling; Kovtun, Mikhail; Stolc, Viktor; Deng, Xing-Wang; Sakakibara, Hitoshi; Kojima, Mikiko (Plant Physiol, 2011-11)
      SHORT-ROOT (SHR) is a key regulator of root growth and development in Arabidopsis (Arabidopsis thaliana). Made in the stele, the SHR protein moves into an adjacent cell layer, where it specifies endodermal cell fate; it ...
    • Homeostasis despite instability. 

      Duncan, W; Best, J; Golubitsky, M; Nijhout, HF; Reed, M (Mathematical biosciences, 2018-06)
      We have shown previously that different homeostatic mechanisms in biochemistry create input-output curves with a "chair" shape. At equilibrium, for intermediate values of a parameter (often an input), a variable, Z, changes ...
    • Homeostasis-Bifurcation Singularities and Identifiability of Feedforward Networks 

      Duncan, William (2020)
      This dissertation addresses two aspects of dynamical systems arising from biological networks: homeostasis-bifurcation and identifiability.Homeostasis occurs when a biological quantity does not change very much as a parameter ...
    • Homeostatic imbalance of purine catabolism in first-episode neuroleptic-naïve patients with schizophrenia. 

      Yao, Jeffrey K; Dougherty, George G; Reddy, Ravinder D; Keshavan, Matcheri S; Montrose, Debra M; Matson, Wayne R; McEvoy, Joseph; ... (8 authors) (PLoS One, 2010-03-03)
      BACKGROUND: Purine catabolism may be an unappreciated, but important component of the homeostatic response of mitochondria to oxidant stress. Accumulating evidence suggests a pivotal role of oxidative stress in schizophrenia ...
    • Mechanism of neuroprotective mitochondrial remodeling by PKA/AKAP1. 

      Merrill, Ronald A; Dagda, Ruben K; Dickey, Audrey S; Cribbs, J Thomas; Green, Steven H; Usachev, Yuriy M; Strack, Stefan (PLoS Biol, 2011-04)
      Mitochondrial shape is determined by fission and fusion reactions catalyzed by large GTPases of the dynamin family, mutation of which can cause neurological dysfunction. While fission-inducing protein phosphatases have been ...
    • microRNA Regulation of Cellular Immunity 

      Lykken, Erik Allen (2016)
      Immunity is broadly defined as a mechanism of protection against non-self entities, a process which must be sufficiently robust to both eliminate the initial foreign body and then be maintained over the life of the host. ...
    • Neuroprotection resulting from insufficiency of RANBP2 is associated with the modulation of protein and lipid homeostasis of functionally diverse but linked pathways in response to oxidative stress. 

      Cho, Kyoung-in; Yi, Haiqing; Tserentsoodol, Nomingerel; Searle, Kelly; Ferreira, Paulo A (Dis Model Mech, 2010-09)
      Oxidative stress is a deleterious stressor associated with a plethora of disease and aging manifestations, including neurodegenerative disorders, yet very few factors and mechanisms promoting the neuroprotection of photoreceptor ...
    • Serotonin synthesis, release and reuptake in terminals: a mathematical model. 

      Best, Janet; Nijhout, H Frederik; Reed, Michael (Theor Biol Med Model, 2010-08-19)
      BACKGROUND: Serotonin is a neurotransmitter that has been linked to a wide variety of behaviors including feeding and body-weight regulation, social hierarchies, aggression and suicidality, obsessive compulsive disorder, ...
    • The liver kinase B1 is a central regulator of T cell development, activation, and metabolism. 

      MacIver, Nancie J; Blagih, Julianna; Saucillo, Donte C; Tonelli, Luciana; Griss, Takla; Rathmell, Jeffrey C; Jones, Russell G (J Immunol, 2011-10-15)
      T cell activation leads to engagement of cellular metabolic pathways necessary to support cell proliferation and function. However, our understanding of the signal transduction pathways that regulate metabolism and their ...