Browsing by Subject "Hsp90"
Now showing items 1-4 of 4
-
Extracellular Hsp90 is Actively Trafficked and Internalized in Breast Cancer Cells
(2016)Despite its ubiquitous abundance, Hsp90 inhibitors have shown promise in anti-cancer clinical trials, suggesting that Hsp90 inhibitors selectively target tumor cells while exhibiting minimal effects in normal cells. Extracellular ... -
Identification of Essential Functions of GRP94 in Metazoan Growth Control and Epithelial Homeostasis
(2009)GRP94, the endoplasmic reticulum Hsp90, is a metazoan-restricted chaperone essential for early development in mammals, yet dispensable for mammalian cell viability. These data suggest that GRP94 is required for important ... -
Leveraging Tumor Stress Responses for a See and Treat Paradigm in Breast Cancer: Applications in Local and Global Health
(2018)With the widespread adoption of mammograms for early breast cancer detection in high income countries (HICs), modern research has principally pivoted towards a focus on reducing overtreatment of patients, particularly those ... -
Regulation of the Apoptosome in Cancer
(2012)Apoptosis is a cellular suicide program that can be initiated by various genotoxic and cytotoxic stimuli. In many cases, such cell damaging agents promote cell death through the intrinsic apoptotic pathway by triggering ...
