Browsing by Subject "Hypoxia"
Now showing items 1-15 of 15
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Amyloid Precursor Protein-Dependent and -Independent Mechanisms in Hypoxia-Induced Axonopathy
(2012)Hypoxia is a profound stressor of the central nervous system implicated in numerous neurodegenerative diseases. While it is increasingly evident that the early effects of hypoxia cause impairment at the level of the axon, ... -
Differential Angiogenic Capability and Hypoxia Responses in Glioma Stem Cells
(2009)Malignant gliomas are highly lethal cancers characterized by florid angiogenesis. Glioma stem cells (GSCs), enriched through CD133 (Prominin1) selection, are highly tumorigenic and therapy resistance. However, the mechanism ... -
Interception of host angiogenic signalling limits mycobacterial growth.
(Nature, 2015-01-29)Pathogenic mycobacteria induce the formation of complex cellular aggregates called granulomas that are the hallmark of tuberculosis. Here we examine the development and consequences of vascularization of the tuberculous ... -
Oxygen for relief of dyspnoea in mildly- or non-hypoxaemic patients with cancer: a systematic review and meta-analysis.
(Br J Cancer, 2008-01-29)The aim of this study was to determine the efficacy of palliative oxygen for relief of dyspnoea in cancer patients. MEDLINE and EMBASE were searched for randomised controlled trials, comparing oxygen and medical air in cancer ... -
Portable Optical Microscopy of Murine Dorsal Window Chambers for Studying Anesthesia, Hypoxia, and Sepsis
(2019)In vivo imaging is an important scientific tool for studying bio-molecular interactions, but lack of preserved functionality during imaging restricts scientists’ abilities to gain critical knowledge. Structure can be preserved ... -
Regulation of HIF-1α during Hypoxia by DAP5-Induced Translation of PHD2
(2018)Death associated protein 5 (DAP5) is an atypical isoform of the translation initiation scaffold eukaryotic initiation factors 4GI and II (eIF4GI/II), which recruit mRNAs to ribosomes in mammals. Unlike eIF4GI/II, DAP5 binds ... -
Sickle erythrocytes target cytotoxics to hypoxic tumor microvessels and potentiate a tumoricidal response.
(PLoS One, 2013)Resistance of hypoxic solid tumor niches to chemotherapy and radiotherapy remains a major scientific challenge that calls for conceptually new approaches. Here we exploit a hitherto unrecognized ability of sickled erythrocytes ... -
The Development of an In Vivo Mobile Dynamic Microscopy System that Images the Hypoxic Microenvironments of Cancerous Tumors via Fluorescent and Phosphorescent Nanoparticles
(2017)Hypoxic tumor microenvironments have a clear correlation with a lack of radiosensitivity and diminished therapy response. This relationship can be described through the use of fluorescent and phosphorescent nanoparticles ... -
The effects of sleep hypoxia on coagulant factors and hepatic inflammation in emphysematous rats.
(PLoS One, 2010-10-06)OBJECTIVES: To develop a sleep hypoxia (SH) in emphysema (SHE) rat model and to explore whether SHE results in more severe hepatic inflammation than emphysema alone and whether the inflammation changes levels of ... -
The Impacts of Embryonic Polycyclic Aromatic Hydrocarbon and Hypoxia Co-Exposures on Two Model Fish Species
(2019)Organisms are routinely subjected to a variety of environmental and chemical perturbations simultaneously. Often, these multi-stressor exposures result in unpredictable toxicity that occurs through unidentified mechanisms. ... -
The role of hypoxia-inducible factor-1 in hyperthermia-induced tumor reoxygenation and therapy resistance
(2010)Imbalance between oxygen consumption and supply often makes tumors hypoxic (Bristow and Hill 2008). Tumor hypoxia is significantly correlated with aggressive tumor growth, ineffective response to radiation and chemotherapy, ... -
The Welfare Effects of Hypoxia in the North Carolina Brown Shrimp Fishery
(2008-04-25)It is well known that hypoxia undermines the ecosystem functions of estuarine and marine environments. However, understanding the economic effects of hypoxia is critical to evaluating consequences for marine resources and ... -
Tissue engraftment of hypoxic-preconditioned adipose-derived stem cells improves flap viability.
(Wound Repair Regen, 2012-11)Adipose-derived stem cells (ASCs) have the ability to release multiple growth factors in response to hypoxia. In this study, we investigated the potential of ASCs to prevent tissue ischemia. We found conditioned media from ... -
Tissue-Integrating Oxygen Sensors: Continuous Tracking of Tissue Hypoxia.
(Advances in experimental medicine and biology, 2017-01)We describe a simple method of tracking oxygen in real-time with injectable, tissue-integrating microsensors. The sensors are small (500 μm × 500 μm × 5 mm), soft, flexible, tissue-like, biocompatible hydrogel s that have ... -
Validating the Use of Boron Nanoparticles to Quantify Tumor Oxygen Tension in Irradiated Breast Tumors
(2019)Although hypoxia in tumors has long been identified as a key contributor to poor patient outcome, clinical solutions to lessen its deleterious effects have not been forthcoming. One reason is that there have been few means ...
