Browsing by Subject "Immune Evasion"
Now showing items 1-6 of 6
-
Immune evasion pathways and the design of dendritic cell-based cancer vaccines.
(Discov Med, 2016-02)Emerging data is suggesting that the process of dendritic cell (DC) tolerization is an important step in tumorigenesis. Our understanding of the networks within the tumor microenvironment that functionally tolerize DC function ... -
Immunological and virological mechanisms of vaccine-mediated protection against SIV and HIV.
(Nature, 2014-01-23)A major challenge for the development of a highly effective AIDS vaccine is the identification of mechanisms of protective immunity. To address this question, we used a nonhuman primate challenge model with simian ... -
Preexisting compensatory amino acids compromise fitness costs of a HIV-1 T cell escape mutation.
(Retrovirology, 2014-11-19)BACKGROUND: Fitness costs and slower disease progression are associated with a cytolytic T lymphocyte (CTL) escape mutation T242N in Gag in HIV-1-infected individuals carrying HLA-B*57/5801 alleles. However, the impact of ... -
Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9.
(Nature, 2011-11-23)Variable regions 1 and 2 (V1/V2) of human immunodeficiency virus-1 (HIV-1) gp120 envelope glycoprotein are critical for viral evasion of antibody neutralization, and are themselves protected by extraordinary sequence diversity ... -
The impact of host immune status on the within-host and population dynamics of antigenic immune escape.
(J R Soc Interface, 2012-10-07)Antigenically evolving pathogens such as influenza viruses are difficult to control owing to their ability to evade host immunity by producing immune escape variants. Experimental studies have repeatedly demonstrated that ... -
Transmission of single HIV-1 genomes and dynamics of early immune escape revealed by ultra-deep sequencing.
(PLoS One, 2010-08-20)We used ultra-deep sequencing to obtain tens of thousands of HIV-1 sequences from regions targeted by CD8+ T lymphocytes from longitudinal samples from three acutely infected subjects, and modeled viral evolution during ...
