Browsing by Subject "Influenza A Virus, H3N2 Subtype"
Now showing items 1-8 of 8
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A crowdsourced analysis to identify ab initio molecular signatures predictive of susceptibility to viral infection.
(Nature communications, 2018-10-24)The response to respiratory viruses varies substantially between individuals, and there are currently no known molecular predictors from the early stages of infection. Here we conduct a community-based analysis to determine ... -
A host transcriptional signature for presymptomatic detection of infection in humans exposed to influenza H1N1 or H3N2.
(PLoS One, 2013)There is great potential for host-based gene expression analysis to impact the early diagnosis of infectious diseases. In particular, the influenza pandemic of 2009 highlighted the challenges and limitations of traditional ... -
Gene Expression Profiles Link Respiratory Viral Infection, Platelet Response to Aspirin, and Acute Myocardial Infarction.
(PLoS One, 2015)BACKGROUND: Influenza infection is associated with myocardial infarction (MI), suggesting that respiratory viral infection may induce biologic pathways that contribute to MI. We tested the hypotheses that 1) a validated ... -
H3N2 influenza infection elicits more cross-reactive and less clonally expanded anti-hemagglutinin antibodies than influenza vaccination.
(PloS one, 2011-01)During the recent H1N1 influenza pandemic, excess morbidity and mortality was seen in young but not older adults suggesting that prior infection with influenza strains may have protected older subjects. In contrast, a history ... -
Nasopharyngeal Protein Biomarkers of Acute Respiratory Virus Infection.
(EBioMedicine, 2017-03)Infection of respiratory mucosa with viral pathogens triggers complex immunologic events in the affected host. We sought to characterize this response through proteomic analysis of nasopharyngeal lavage in human subjects ... -
Phylodynamic inference and model assessment with approximate bayesian computation: influenza as a case study.
(PLoS Comput Biol, 2012)A key priority in infectious disease research is to understand the ecological and evolutionary drivers of viral diseases from data on disease incidence as well as viral genetic and antigenic variation. We propose using a ... -
Temporal dynamics of host molecular responses differentiate symptomatic and asymptomatic influenza a infection.
(PLoS Genet, 2011-08)Exposure to influenza viruses is necessary, but not sufficient, for healthy human hosts to develop symptomatic illness. The host response is an important determinant of disease progression. In order to delineate host molecular ... -
The impact of host immune status on the within-host and population dynamics of antigenic immune escape.
(J R Soc Interface, 2012-10-07)Antigenically evolving pathogens such as influenza viruses are difficult to control owing to their ability to evade host immunity by producing immune escape variants. Experimental studies have repeatedly demonstrated that ...
