Browsing by Subject "Insulin-Like Growth Factor II"
Now showing items 1-10 of 10
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Association of cord blood methylation fractions at imprinted insulin-like growth factor 2 (IGF2), plasma IGF2, and birth weight.
(Cancer causes & control : CCC, 2012-04)<h4>Purpose</h4>Altered methylation at Insulin-like Growth Factor 2 (IGF2) regulatory regions has previously been associated with obesity, and several malignancies including colon, esophageal, and prostate adenocarcinomas, ... -
Associations between antibiotic exposure during pregnancy, birth weight and aberrant methylation at imprinted genes among offspring.
(International journal of obesity (2005), 2013-07)<h4>Objectives</h4>Low birth weight (LBW) has been associated with common adult-onset chronic diseases, including obesity, cardiovascular disease, type II diabetes and some cancers. The etiology of LBW is multi-factorial. ... -
Depression in pregnancy, infant birth weight and DNA methylation of imprint regulatory elements.
(Epigenetics : official journal of the DNA Methylation Society, 2012-07)Depressed mood in pregnancy has been linked to low birth weight (LBW, 4,500 g) infants had 5.9% higher methylation at the PLAGL1 DMR compared with normal birth weight infants. Our findings confirm that severe maternal depressed ... -
Genetic variants in IGF-I, IGF-II, IGFBP-3, and adiponectin genes and colon cancer risk in African Americans and Whites.
(Cancer Causes Control, 2012-07)PURPOSE: Evaluating genetic susceptibility may clarify effects of known environmental factors and also identify individuals at high risk. We evaluated the association of four insulin-related pathway gene polymorphisms in ... -
Insulin-like growth factor 2/H19 methylation at birth and risk of overweight and obesity in children.
(The Journal of pediatrics, 2012-07)<h4>Objective</h4>To determine whether aberrant DNA methylation at differentially methylated regions (DMRs) regulating insulin-like growth factor 2 (IGF2) expression in umbilical cord blood is associated with overweight ... -
Methylation variation at IGF2 differentially methylated regions and maternal folic acid use before and during pregnancy.
(Epigenetics, 2011-07)Folic acid (FA) supplementation before and during pregnancy has been associated with decreased risk of neural tube defects although recent reports suggest it may also increase the risk of other chronic diseases. We evaluated ... -
Newborns of obese parents have altered DNA methylation patterns at imprinted genes.
(International journal of obesity (2005), 2015-04)Several epidemiologic studies have demonstrated associations between periconceptional environmental exposures and health status of the offspring in later life. Although these environmentally related effects have been attributed ... -
Paternal obesity is associated with IGF2 hypomethylation in newborns: results from a Newborn Epigenetics Study (NEST) cohort.
(BMC medicine, 2013-02-06)<h4>Background</h4>Data from epidemiological and animal model studies suggest that nutrition during pregnancy may affect the health status of subsequent generations. These transgenerational effects are now being explained ... -
Prolactin receptor signaling is essential for perinatal brown adipocyte function: a role for insulin-like growth factor-2.
(PLoS One, 2008-02-06)BACKGROUND: The lactogenic hormones prolactin (PRL) and placental lactogens (PL) play central roles in reproduction and mammary development. Their actions are mediated via binding to PRL receptor (PRLR), highly expressed ... -
Selective expression of insulin-like growth factor II in the songbird brain.
(J Neurosci, 1997-09-15)Neuronal replacement occurs in the forebrain of juvenile and adult songbirds. To address the molecular processes that govern this replacement, we cloned the zebra finch insulin-like growth factor II (IGF-II) cDNA, a factor ...
