Browsing by Subject "K562 Cells"

Engineering a BCR-ABL-activated caspase for the selective elimination of leukemic cells.

Kurokawa, Manabu; Ito, Takahiro; Yang, Chih-Sheng; Zhao, Chen; Macintyre, Andrew N; Rizzieri, David A; Rathmell, Jeffrey C; ... (10 authors) (Proc Natl Acad Sci U S A, 2013-02-05)

Increased understanding of the precise molecular mechanisms involved in cell survival and cell death signaling pathways offers the promise of harnessing these molecules to eliminate cancer cells without damaging normal cells. ...

Morphing low-affinity ligands into high-avidity nanoparticles by thermally triggered self-assembly of a genetically encoded polymer.

Simnick, Andrew J; Valencia, C Alexander; Liu, Rihe; Chilkoti, Ashutosh (ACS Nano, 2010-04-27)

Multivalency is the increase in avidity resulting from the simultaneous interaction of multiple ligands with multiple receptors. This phenomenon, seen in antibody-antigen and virus-cell membrane interactions, is useful in ...

SIV-induced terminally differentiated adaptive NK cells in lymph nodes associated with enhanced MHC-E restricted activity.

Huot, Nicolas; Rascle, Philippe; Petitdemange, Caroline; Contreras, Vanessa; Stürzel, Christina M; Baquero, Eduard; Harper, Justin L; ... (21 authors) (Nature communications, 2021-02-24)

Natural killer (NK) cells play a critical understudied role during HIV infection in tissues. In a natural host of SIV, the African green monkey (AGM), NK cells mediate a strong control of SIVagm infection in secondary lymphoid ...