Browsing by Subject "Kidney Transplantation"

Costimulation blockade alters germinal center responses and prevents antibody-mediated rejection.

Farris, AB; Gibby, Adriana C; Hong, JJ; Iwakoshi, Neal N; Kim, EJ; Kirk, Allan D; Knechtle, Stuart J; ... (9 authors) (Am J Transplant, 2014-01)

De novo donor-specific antibody (DSA) after organ transplantation promotes antibody-mediated rejection (AMR) and causes late graft loss. Previously, we demonstrated that depletion using anti-CD3 immunotoxin combined with ...

Interleukin-15 receptor blockade in non-human primate kidney transplantation.

Faure, JP; Fechner, J; Haustein, S; Kayaoglu, A; Knechtle, Stuart J; Kwun, J; Roenneburg, D; ... (8 authors) (Transplantation, 2010-04-27)

BACKGROUND: Interleukin (IL)-15 is a chemotactic factor to T cells. It induces proliferation and promotes survival of activated T cells. IL-15 receptor blockade in mouse cardiac and islet allotransplant models has led to ...

Neutralizing BAFF/APRIL with atacicept prevents early DSA formation and AMR development in T cell depletion induced nonhuman primate AMR model.

Farris, AB; Gibby, Adriana C; Hong, JJ; Knechtle, Stuart J; Kwun, J; Page, EK; Villinger, F; ... (8 authors) (Am J Transplant, 2015-03)

Depletional strategies directed toward achieving tolerance induction in organ transplantation have been associated with an increased incidence and risk of antibody-mediated rejection (AMR) and graft injury. Our clinical ...

The providing resources to enhance African American patients' readiness to make decisions about kidney disease (PREPARED) study: protocol of a randomized controlled trial.

Ameling, J; Auguste, P; Boulware, Ebony; Crews, DC; DePasquale, N; Ephraim, Patti L; Greer, RC; ... (12 authors) (BMC Nephrol, 2012-10-12)

BACKGROUND: Living related kidney transplantation (LRT) is underutilized, particularly among African Americans. The effectiveness of informational and financial interventions to enhance informed decision-making among African ...

The TALKS study to improve communication, logistical, and financial barriers to live donor kidney transplantation in African Americans: protocol of a randomized clinical trial.

Boulware, Ebony; Darrell, L; Ellis, M; Ephraim, Patti L; Falkovic, Margaret; Hill-Briggs, F; Kaiser, M; ... (14 authors) (BMC Nephrol, 2015-10-09)

BACKGROUND: Live donor kidney transplantation (LDKT), an optimal therapy for many patients with end-stage kidney disease, is underutilized, particularly by African Americans. Potential recipient difficulties initiating and ...