Browsing by Subject "Kinetochores"

Now showing items 1-3 of 3

    • Alpha satellite DNA biology: finding function in the recesses of the genome. 

      McNulty, Shannon M; Sullivan, Beth A (Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 2018-09)
      Repetitive DNA, formerly referred to by the misnomer "junk DNA," comprises a majority of the human genome. One class of this DNA, alpha satellite, comprises up to 10% of the genome. Alpha satellite is enriched at all human ...

    • Functional epialleles at an endogenous human centromere. 

      Maloney, Kristin A; Sullivan, Lori L; Matheny, Justyne E; Strome, Erin D; Merrett, Stephanie L; Ferris, Alyssa; Sullivan, Beth A (Proc Natl Acad Sci U S A, 2012-08-21)
      Human centromeres are defined by megabases of homogenous alpha-satellite DNA arrays that are packaged into specialized chromatin marked by the centromeric histone variant, centromeric protein A (CENP-A). Although most human ...

    • How the kinetochore couples microtubule force and centromere stretch to move chromosomes. 

      Suzuki, Aussie; Badger, Benjamin L; Haase, Julian; Ohashi, Tomoo; Erickson, Harold P; Salmon, Edward D; Bloom, Kerry (Nature cell biology, 2016-04)
      The Ndc80 complex (Ndc80, Nuf2, Spc24 and Spc25) is a highly conserved kinetochore protein essential for end-on anchorage to spindle microtubule plus ends and for force generation coupled to plus-end polymerization ...