Browsing by Subject "Liposomes"
Now showing items 1-9 of 9
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Chapter 1 - Tubular liposomes with variable permeability for reconstitution of FtsZ rings.
(Methods in enzymology, 2009-01)We have developed a system for producing tubular multilamellar liposomes that incorporate the protein FtsZ on the inside. We start with a mixture of spherical multilamellar liposomes with FtsZ initially on the outside. Shearing ... -
Computed tomography imaging of primary lung cancer in mice using a liposomal-iodinated contrast agent.
(PLoS One, 2012)PURPOSE: To investigate the utility of a liposomal-iodinated nanoparticle contrast agent and computed tomography (CT) imaging for characterization of primary nodules in genetically engineered mouse models of non-small cell ... -
Curved FtsZ protofilaments generate bending forces on liposome membranes.
(The EMBO journal, 2009-11)We have created FtsZ-YFP-mts where an amphipathic helix on the C-terminus tethers FtsZ to the membrane. When incorporated inside multi-lamellar tubular liposomes, FtsZ-YFP-mts can assemble Z rings that generate a constriction ... -
Dual-energy micro-CT functional imaging of primary lung cancer in mice using gold and iodine nanoparticle contrast agents: a validation study.
(PLoS One, 2014)PURPOSE: To provide additional functional information for tumor characterization, we investigated the use of dual-energy computed tomography for imaging murine lung tumors. Tumor blood volume and vascular permeability were ... -
Inside-out Z rings--constriction with and without GTP hydrolysis.
(Molecular microbiology, 2011-07)The bacterial tubulin homologue FtsZ forms a ring-like structure called the Z ring that drives cytokinesis. We showed previously that FtsZ-YFP-mts, which has a short amphipathic helix (mts) on its C terminus that inserts ... -
Micro-CT imaging of breast tumors in rodents using a liposomal, nanoparticle contrast agent.
(Int J Nanomedicine, 2009)A long circulating liposomal, nanoscale blood pool agent encapsulating traditional iodinated contrast agent (65 mg I/mL) was used for micro-computed tomography (CT) imaging of rats implanted with R3230AC mammary carcinoma. ... -
Negative-stain electron microscopy of inside-out FtsZ rings reconstituted on artificial membrane tubules show ribbons of protofilaments.
(Biophysical journal, 2012-07)FtsZ, the primary cytoskeletal element of the Z ring, which constricts to divide bacteria, assembles into short, one-stranded filaments in vitro. These must be further assembled to make the Z ring in bacteria. Conventional ... -
Recording Information into DNA
(2009)The objective of this research is to develop the concept of "genetic memory", the storage of information into genetic material, through the demonstration of the feasibility and benefits of recording the time-history of one ... -
Unique Contributions of iDQC MR Contrast to Stimuli-Sensitive Liposomal Chemotherapy and Imaging
(2012)Liposomes are excellent chemotherapy drug delivery agents, on the cutting edge of cancer treatment technology. Since liposomes are already used to deploy cancer drugs in patients, imaging capacity would make them dual-purpose ...
