Browsing by Subject "Lymphocyte Depletion"

Enhanced de novo alloantibody and antibody-mediated injury in rhesus macaques.

Gibby, Adriana C; Hennigar, RA; Iwakoshi, Neal N; Jenkins, JB; Knechtle, Stuart J; Kwun, J; Leopardi, F; ... (11 authors) (Am J Transplant, 2012-09)

Chronic allograft rejection is a major impediment to long-term transplant success. Humoral immune responses to alloantigens are a growing clinical problem in transplantation, with mounting evidence associating alloantibodies ...

Inhibition of adaptive immune responses leads to a fatal clinical outcome in SIV-infected pigtailed macaques but not vervet African green monkeys.

Allan, JS; Brown, CR; Byrum, RA; Goldstein, S; Hirsch, VM; Kaur, A; Li, M; ... (13 authors) (PLoS Pathog, 2009-12)

African green monkeys (AGM) and other natural hosts for simian immunodeficiency virus (SIV) do not develop an AIDS-like disease following SIV infection. To evaluate differences in the role of SIV-specific adaptive immune ...

Myeloablative temozolomide enhances CD8⁺ T-cell responses to vaccine and is required for efficacy against brain tumors in mice.

Archer, GE; Bigner, DD; Choi, BD; Cui, X; Flores, C; Herndon, James Emmett II; Johnson, LA; ... (12 authors) (PLoS One, 2013)

Temozolomide (TMZ) is an alkylating agent shown to prolong survival in patients with high grade glioma and is routinely used to treat melanoma brain metastases. A prominent side effect of TMZ is induction of profound lymphopenia, ...

Neutralizing BAFF/APRIL with atacicept prevents early DSA formation and AMR development in T cell depletion induced nonhuman primate AMR model.

Farris, AB; Gibby, Adriana C; Hong, JJ; Knechtle, Stuart J; Kwun, J; Page, EK; Villinger, F; ... (8 authors) (Am J Transplant, 2015-03)

Depletional strategies directed toward achieving tolerance induction in organ transplantation have been associated with an increased incidence and risk of antibody-mediated rejection (AMR) and graft injury. Our clinical ...

Prevention trumps treatment of antibody-mediated transplant rejection.

Iwakoshi, Neal N; Knechtle, Stuart J; Kwun, J (J Clin Invest, 2010-04)

Belying the spectacular success of solid organ transplantation and improvements in immunosuppressive therapy is the reality that long-term graft survival rates remain relatively unchanged, in large part due to chronic and ...