Browsing by Subject "Metabolism"
Now showing items 1-20 of 20
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Aerobic Training-Induced Host Changes Alter Breast Cancer Cell Phenotypes and Tumor Progression
(2015)A growing number of studies have investigated the role of exercise both during and after a breast cancer diagnosis. Observational data suggests that regular endurance exercise is associated with a 20-50% reduction ... -
Coupling of the Yeast Metabolic Cycle and the Cell Division Cycle in Populations and Single Cells
(2017)Biological oscillators are ubiquitous in living systems. They allow cellular processes to anticipate and act in synchrony with regular events in the outside world (such as the day/night cycle), or they ensure that processes ... -
Digital Environmental Metabolisms: An Ecocritical Project of the Digital Environmental Humanities
(2017)By combining literary, ecocritical, and media techniques with a mindfulness of the environment, “Digital Environmental Metabolisms: An Ecocritical Project of the Digital Environmental Humanities” contributes to the urgent ... -
Dynamic Regulation of Metabolism in Archaea
(2015)The regulation of metabolism is one of the key challenges faced by organisms across all domains of life. Despite fluctuating environments, cells must produce the same metabolic outputs to thrive. Although much is known about ... -
Effects of Proximal Tubule Angiotensin II Signaling on Energy Metabolism in the Kidney
(2017-12-12)Chronic kidney disease (CKD) affects over 26 million adults in the United States, thus it is imperative that we deduce more about the pathogenesis of the disease. CKD is generally multi-factorial, and loss of renal function ... -
Fibroblast Growth Factor 13 Regulates Thermogenesis and Metabolism
(2019)The non-secreted fibroblast growth factor (FGF) homologous factor (FHF) FGF13 is a noncanonical FGF with identified roles in neuronal development, pain sensation, and cardiac physiology, but recent reports suggest broader ... -
Harnessing T Cell Generation and Metabolism to Modulate T Cell Recovery Following Radiation Exposure and Bone Marrow Transplantation
(2022)Total body irradiation (TBI) causes profound suppression of hematopoiesis and T cell depletion, increasing chances of morbidity associated with opportunistic infections in the lymphopenic condition. Currently, therapeutic ... -
Heritability estimates of endophenotypes of long and health life: the Long Life Family Study.
(J Gerontol A Biol Sci Med Sci, 2010-12)BACKGROUND: Identification of gene variants that contribute to exceptional survival may provide critical biologic information that informs optimal health across the life span. METHODS: As part of phenotype development efforts ... -
Homeostatic imbalance of purine catabolism in first-episode neuroleptic-naïve patients with schizophrenia.
(PLoS One, 2010-03-03)BACKGROUND: Purine catabolism may be an unappreciated, but important component of the homeostatic response of mitochondria to oxidant stress. Accumulating evidence suggests a pivotal role of oxidative stress in schizophrenia ... -
Identification of Molecular Determinants of Cellular Senescence in Cancer and Aging
(2018)Cellular senescence is a fundamental cell fate playing significant and complex roles during tumorigenesis and natural aging process. However, the molecular determinants distinguishing senescence from other temporary and ... -
Investigating the Intrinsic and Extrinsic Drivers of Primate Heterothermy
(2016)Seasonal heterothermy—an orchestrated set of extreme physiological responses—is directly responsible for the over-winter survival of many mammalian groups living in seasonal environments. Historically, it was thought that ... -
Metabolic Regulation of Mast Cell Regranulation
(2021)Mast cells (MCs) are long-lived hematopoietic cells located within tissues. These cells are densely packed with granules containing preformed bioactive components that are released within seconds to minutes upon activation ... -
Metaboloptics: In Vivo Optical Imaging to Enable Simultaneous Measurement of Glucose Uptake, Mitochondrial Membrane Potential, and Vascular Features in Cancer
(2016)Altered metabolism is a hallmark of almost all cancers. A tumor’s metabolic phenotype can drastically change its ability to proliferate and to survive stressors such as hypoxia or therapy. Metabolism can be used as a diagnostic ... -
Non-Lysine Acyl Modifications and Their Effects on Cellular Function
(2021)In recent years, our understanding of the scope and diversity of protein post-translational modifications has rapidly expanded. While mitochondrial proteins in particular have been studied in detail and are decorated with ... -
Regulation of Cartilage Tumors by Mutations in Isocitrate Dehydrogenases
(2021)Enchondroma and chondrosarcoma are common benign and malignant cartilaginous neoplasms. Mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2) are present in the majority of these tumors. Mutant IDH enzymes gain a neomorphic ... -
Shifting thermal and metabolic regimes in a low gradient, temperate river network
(2021)Rivers transform more than half of the organic inputs they receive from terrestrial systems through metabolic processes. In addition to providing the energetic base to sustain stream food webs, these transformations are ... -
The Role of Acetylation in the Metabolic Reprogramming of Cancer Cells
(2016)Identifying metabolic vulnerabilities of cancer cells remains a subject of investigation for the identification of potential metabolically based therapies for cancer. It is well known that proliferating cells become largely ... -
The Role of SIRT3 and Acetylation in the Pathogenesis of Friedreich’s Ataxia Cardiomyopathy
(2017)Lysine acetylation and its regulation by the mitochondrial NAD+-dependent protein deacetylase sirtuin 3 (SIRT3) are emerging as important regulators of cardiac pathophysiology. SIRT3 serves as a negative regulator of cardiac ... -
Transcriptomic and Metabolic Heterogeneity During Epstein-Barr Virus Latency Establishment
(2019)Epstein-Barr Virus (EBV) is a ubiquitous gamma-herpesvirus in the human population and highly associated with lymphomas of the immune-suppressed. EBV maintains itself within the human host via temporal regulation of viral ... -
Uncovering a Novel Role of the Apoptotic Initiator Caspase, Caspase-2
(2014)With the prevalence of obesity and metabolic syndrome rising sharply world-wide, it has become increasingly important to define the molecular mechanisms underlying the pathogenesis and progression of diseases associated ...
