Browsing by Subject "Metabolomics"
Now showing items 1-11 of 11
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Genetic Dissection of the Biological and Molecular Role of IDH1 Mutations in Glioma
(2012)Gliomas are tumors of the central nervous system for which improvements in treatment are critically needed. Mutations in IDH1 and IDH2, which encode the cytosolic and mitochondrial NADP+-dependent isocitrate dehydrogenases, ... -
Improving Mass Spectrometry-Based Metabolite Identification and Quantification and Application to Cardiovascular Disease
(2017)High-throughput molecular profiling is being increasingly applied to identify novel biomarkers and mechanisms of health and disease. One such application is the use of mass spectrometry-based metabolomic profiling ... -
Metabolomic derangements are associated with mortality in critically ill adult patients.
(PLoS One, 2014)OBJECTIVE: To identify metabolomic biomarkers predictive of Intensive Care Unit (ICU) mortality in adults. RATIONALE: Comprehensive metabolomic profiling of plasma at ICU admission to identify biomarkers associated with ... -
Metabolomic Quantitative Trait Loci (mQTL) Mapping Implicates the Ubiquitin Proteasome System in Cardiovascular Disease Pathogenesis.
(PLoS Genet, 2015-11)Levels of certain circulating short-chain dicarboxylacylcarnitine (SCDA), long-chain dicarboxylacylcarnitine (LCDA) and medium chain acylcarnitine (MCA) metabolites are heritable and predict cardiovascular disease (CVD) ... -
Metabolomic signature of exposure and response to citalopram/escitalopram in depressed outpatients.
(Translational psychiatry, 2019-07-04)Metabolomics provides valuable tools for the study of drug effects, unraveling the mechanism of action and variation in response due to treatment. In this study we used electrochemistry-based targeted metabolomics to gain ... -
Molecular alterations in skeletal muscle in rheumatoid arthritis are related to disease activity, physical inactivity, and disability.
(Arthritis Res Ther, 2017-01-23)BACKGROUND: To identify molecular alterations in skeletal muscle in rheumatoid arthritis (RA) that may contribute to ongoing disability in RA. METHODS: Persons with seropositive or erosive RA (n = 51) and control subjects ... -
Pharmacometabolomics of response to sertraline and to placebo in major depressive disorder - possible role for methoxyindole pathway.
(PloS one, 2013-01)Therapeutic response to selective serotonin (5-HT) reuptake inhibitors in Major Depressive Disorder (MDD) varies considerably among patients, and the onset of antidepressant therapeutic action is delayed until after 2 to ... -
Phosphoproteomic profiling of human myocardial tissues distinguishes ischemic from non-ischemic end stage heart failure.
(PLoS One, 2014)The molecular differences between ischemic (IF) and non-ischemic (NIF) heart failure are poorly defined. A better understanding of the molecular differences between these two heart failure etiologies may lead to the development ... -
Ranbp2 haploinsufficiency mediates distinct cellular and biochemical phenotypes in brain and retinal dopaminergic and glia cells elicited by the Parkinsonian neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
(Cell Mol Life Sci, 2012-10)Many components and pathways transducing multifaceted and deleterious effects of stress stimuli remain ill-defined. The Ran-binding protein 2 (RanBP2) interactome modulates the expression of a range of clinical ... -
Renal systems biology of patients with systemic inflammatory response syndrome.
(Kidney Int, 2015-10)A systems biology approach was used to comprehensively examine the impact of renal disease and hemodialysis (HD) on patient response during critical illness. To achieve this, we examined the metabolome, proteome, ... -
The role of metabolomics in osteoarthritis research.
(J Am Acad Orthop Surg, 2013-01)
