Browsing by Subject "Methionine"
Now showing items 1-6 of 6
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A population model of folate-mediated one-carbon metabolism.
(Nutrients, 2013-07-05)BACKGROUND: Previous mathematical models for hepatic and tissue one-carbon metabolism have been combined and extended to include a blood plasma compartment. We use this model to study how the concentrations of metabolites ... -
Binding of MetJ repressor to specific and nonspecific DNA and effect of S-adenosylmethionine on these interactions.
(Biochemistry, 2010-04-20)We have used analytical ultracentrifugation to characterize the binding of the methionine repressor protein, MetJ, to synthetic oligonucleotides containing zero to five specific recognition sites, called metboxes. For all ... -
Characterization of Metal Binding Peptides Derived from Copper Trafficking Proteins
(2010)Copper was first released into the environment as the result of the mass generation of oxygen from photosynthetic bacteria roughly 2.7 billion years ago. While it proved to be poisonous to early life on Earth, those that ... -
Coordination of platinum therapeutic agents to met-rich motifs of human copper transport protein1.
(Metallomics, 2010-01)Platinum therapeutic agents are widely used in the treatment of several forms of cancer. Various mechanisms for the transport of the drugs have been proposed including passive diffusion across the cellular membrane and active ... -
Genetic Variants in RUNX3, AMD1 and MSRA in the Methionine Metabolic Pathway and Survival in Non-small Cell Lung Cancer Patients.
(International journal of cancer, 2019-01-16)Abnormal methionine dependence in cancer cells has led to methionine restriction as a potential therapeutic strategy. We hypothesized that genetic variants involved in methionine-metabolic genes are associated with survival ... -
Mass spectrometry-based thermal shift assay for protein-ligand binding analysis.
(Anal Chem, 2010-07-01)Described here is a mass spectrometry-based screening assay for the detection of protein-ligand binding interactions in multicomponent protein mixtures. The assay utilizes an oxidation labeling protocol that involves using ...
