Browsing by Subject "Mice, 129 Strain"

Now showing items 1-5 of 5

    • A Peptide Uncoupling BDNF Receptor TrkB from Phospholipase Cγ1 Prevents Epilepsy Induced by Status Epilepticus. 

      Gu, Bin; Huang, Yang Zhong; He, Xiao-Ping; Joshi, Rasesh B; Jang, Wonjo; McNamara, James O (Neuron, 2015-11-04)
      The BDNF receptor tyrosine kinase, TrkB, underlies nervous system function in both health and disease. Excessive activation of TrkB caused by status epilepticus promotes development of temporal lobe epilepsy (TLE), revealing ...

    • Gene expression-based classifiers identify Staphylococcus aureus infection in mice and humans. 

      Ahn, Sun Hee; Tsalik, Ephraim L; Cyr, Derek D; Zhang, Yurong; van Velkinburgh, Jennifer C; Langley, Raymond J; Glickman, Seth W; ... (18 authors) (PLoS One, 2013)
      Staphylococcus aureus causes a spectrum of human infection. Diagnostic delays and uncertainty lead to treatment delays and inappropriate antibiotic use. A growing literature suggests the host's inflammatory response to the ...

    • Genome-wide identification of autosomal genes with allelic imbalance of chromatin state. 

      Savol, Andrej J; Wang, Peggy I; Jeon, Yesu; Colognori, David; Yildirim, Eda; Pinter, Stefan F; Payer, Bernhard; ... (9 authors) (PloS one, 2017-01)
      In mammals, monoallelic gene expression can result from X-chromosome inactivation, genomic imprinting, and random monoallelic expression (RMAE). Epigenetic regulation of RMAE is not fully understood. Here we analyze allelic ...

    • Persisting neurobehavioral effects of developmental copper exposure in wildtype and metallothionein 1 and 2 knockout mice. 

      Petro, Ann; Sexton, Hannah G; Miranda, Caroline; Rastogi, Anit; Freedman, Jonathan H; Levin, Edward D (BMC pharmacology & toxicology, 2016-11)
      <h4>Background</h4>Metallothioneins (MT) are small proteins, which are crucial for the distribution of heavy and transition metals. Previously, we found in mice that knockout of MT 1 and 2 genes (MTKO) impaired spatial learning ...

    • Type 2 alveolar cells are stem cells in adult lung. 

      Barkauskas, Christina E; Cronce, Michael J; Rackley, Craig R; Bowie, Emily J; Keene, Douglas R; Stripp, Barry R; Randell, Scott H; ... (9 authors) (The Journal of clinical investigation, 2013-07)
      Gas exchange in the lung occurs within alveoli, air-filled sacs composed of type 2 and type 1 epithelial cells (AEC2s and AEC1s), capillaries, and various resident mesenchymal cells. Here, we use a combination of in vivo ...