Browsing by Subject "MicroRNAs"
Now showing items 1-20 of 32
-
A functional variant at miRNA-122 binding site in IL-1a 3' UTR predicts risk of recurrence in patients with oropharyngeal cancer.
(Oncotarget, 2016-06)IL-1a, an important regulator of immune and inflammation responses, has been implicated in cancer development and prognosis. An insertion (Ins)/deletion (Del) polymorphism (IL-1a rs3783553) in the 3' UTR of IL-1a may disrupt ... -
A miR-34a-Numb Feedforward Loop Triggered by Inflammation Regulates Asymmetric Stem Cell Division in Intestine and Colon Cancer.
(Cell Stem Cell, 2016-02-04)Emerging evidence suggests that microRNAs can initiate asymmetric division, but whether microRNA and protein cell fate determinants coordinate with each other remains unclear. Here, we show that miR-34a directly suppresses ... -
A pri-miR-218 variant and risk of cervical carcinoma in Chinese women.
(BMC cancer, 2013-01-15)BACKGROUND: MicroRNA (miRNA)-related single nucleotide polymorphisms (SNPs) may compromise miRNA binding affinity and modify mRNA expression levels of the target genes, thus leading to cancer susceptibility. However, few ... -
A TGF-β1 genetic variant at the miRNA187 binding site significantly modifies risk of HPV16-associated oropharyngeal cancer.
(International journal of cancer, 2018-09)TGF-β1rs1982073 polymorphism at the miRNA-187 binding site may alter TGF-β1 expression and function, and thereby this polymorphism (genotype CT/CC) increases cancer susceptibility. HPV16 L1 seropositivity is associated with ... -
An integrated approach to the prediction of chemotherapeutic response in patients with breast cancer.
(PLoS One, 2008-04-02)BACKGROUND: A major challenge in oncology is the selection of the most effective chemotherapeutic agents for individual patients, while the administration of ineffective chemotherapy increases mortality and decreases quality ... -
Anti-fibrotic effects of different sources of MSC in bleomycin-induced lung fibrosis in C57BL6 male mice.
(Respirology (Carlton, Vic.), 2021-02)<h4>Background and objective</h4>IPF is a fatal and debilitating lung disorder increasing in incidence worldwide. To date, two approved treatments only slow disease progression, have multiple side effects and do not provide ... -
Assessing the utility of thermodynamic features for microRNA target prediction under relaxed seed and no conservation requirements.
(PLoS One, 2011)BACKGROUND: Many computational microRNA target prediction tools are focused on several key features, including complementarity to 5'seed of miRNAs and evolutionary conservation. While these features allow for successful ... -
Chromosome 19 microRNAs exert antiviral activity independent from type III interferon signaling.
(Placenta, 2018-01)INTRODUCTION:Cultured primary human trophoblasts (PHT), derived from term placentas, are relatively resistant to infection by diverse viruses. The resistance can be conferred to non-trophoblastic cells by pre-exposing them ... -
Dermal exosomes containing miR-218-5p promote hair regeneration by regulating β-catenin signaling.
(Science advances, 2020-07)The progression in the hair follicle cycle from the telogen to the anagen phase is the key to regulating hair regrowth. Dermal papilla (DP) cells support hair growth and regulate the hair cycle. However, they gradually lose ... -
Effect of microRNA modulation on bioartificial muscle function.
(Tissue Eng Part A, 2010-12)Cellular therapies have recently employed the use of small RNA molecules, particularly microRNAs (miRNAs), to regulate various cellular processes that may be altered in disease states. In this study, we examined the effect ... -
Five questions about viruses and microRNAs.
(PLoS Pathog, 2010-02-26) -
Identification of microRNAs expressed in two mosquito vectors, Aedes albopictus and Culex quinquefasciatus.
(BMC Genomics, 2010-02-18)BACKGROUND: MicroRNAs (miRNAs) are small non-coding RNAs that post-transcriptionally regulate gene expression in a variety of organisms, including insects, vertebrates, and plants. miRNAs play important roles in cell development ... -
Large-Scale microRNA Expression Profiling Identifies Putative Retinal miRNA-mRNA Signaling Pathways Underlying Form-Deprivation Myopia in Mice.
(PLoS One, 2016)Development of myopia is associated with large-scale changes in ocular tissue gene expression. Although differential expression of coding genes underlying development of myopia has been a subject of intense investigation, ... -
MicroRNA antagonism of the picornaviral life cycle: alternative mechanisms of interference.
(PLoS Pathog, 2010-03-19)In addition to modulating the function and stability of cellular mRNAs, microRNAs can profoundly affect the life cycles of viruses bearing sequence complementary targets, a finding recently exploited to ameliorate toxicities ... -
MicroRNA variants increase the risk of HPV-associated squamous cell carcinoma of the oropharynx in never smokers.
(PloS one, 2013-01)Both microRNAs and human papillomavirus (HPV) infection play an important role in the development and progression of oral squamous cell carcinoma (OSCC). In addition, microRNAs affect all facets of the immune/inflammation ... -
microRNA-21-5p dysregulation in exosomes derived from heart failure patients impairs regenerative potential.
(The Journal of clinical investigation, 2019-04)Exosomes, as functional paracrine units of therapeutic cells, can partially reproduce the reparative properties of their parental cells. The constitution of exosomes, as well as their biological activity, largely depends ... -
MiR-215 Is Induced Post-transcriptionally via HIF-Drosha Complex and Mediates Glioma-Initiating Cell Adaptation to Hypoxia by Targeting KDM1B.
(Cancer Cell, 2016-01-11)The hypoxic tumor microenvironment serves as a niche for maintaining the glioma-initiating cells (GICs) that are critical for glioblastoma (GBM) occurrence and recurrence. Here, we report that hypoxia-induced miR-215 is ... -
Neuron-specific Sumo1-3 knockdown in mice impairs episodic and fear memories.
(Journal of psychiatry & neuroscience : JPN, 2014-07)BACKGROUND:Growing evidence suggests that small ubiquitin-like modifier (SUMO) conjugation plays a key role in brain plasticity by modulating activity-dependent synaptic transmission. However, these observations are based ... -
Plasma miRNAs as early biomarkers for detecting hepatocellular carcinoma.
(Int J Cancer, 2015-10-01)The early detection of hepatocellular carcinoma (HCC) presents a challenge because of the lack of specific biomarkers. Serum/plasma microRNAs (miRNAs) can discriminate HCC patients from controls. We aimed to identify and ... -
Polymorphisms at the microRNA binding-site of the stem cell marker gene CD133 modify susceptibility to and survival of gastric cancer.
(Mol Carcinog, 2015-06)CD133 is one of the most common stem cell markers, and functional single nucleotide polymorphisms (SNPs) of CD133 may modulate its gene functions and thus cancer risk and patient survival. We hypothesized that potentially ...
