Browsing by Subject "Microbial Sensitivity Tests"
Now showing items 1-16 of 16
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A Multicountry Molecular Analysis of Salmonella enterica Serovar Typhi With Reduced Susceptibility to Ciprofloxacin in Sub-Saharan Africa.
(Clin Infect Dis, 2016-03-15)BACKGROUND: Salmonella enterica serovar Typhi is a predominant cause of bloodstream infections in sub-Saharan Africa (SSA). Increasing numbers of S. Typhi with resistance to ciprofloxacin have been reported from different ... -
Antimicrobial-Resistant Shigella spp. in San Diego, California, USA, 2017-2020.
(Emerging infectious diseases, 2022-06)Annually, Shigella spp. cause ≈188 million cases of diarrheal disease globally, including 500,000 cases in the United States; rates of antimicrobial resistance are increasing. To determine antimicrobial resistance and risk ... -
Bloodstream infections in community hospitals in the 21st century: a multicenter cohort study.
(PLoS One, 2014)BACKGROUND: While the majority of healthcare in the US is provided in community hospitals, the epidemiology and treatment of bloodstream infections in this setting is unknown. METHODS AND FINDINGS: We undertook this multicenter, ... -
Cationic amphiphilic Zn-porphyrin with high antifungal photodynamic potency.
(Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2017-11)Photodynamic therapy (PDT) is a promising alternative approach particularly attractive for treatment of localized fungal infections. It is based on compounds, photosensitizers (PSs), which when excited with visible light, ... -
Characterization of the FKBP12-Encoding Genes in Aspergillus fumigatus.
(PLoS One, 2015)Invasive aspergillosis, largely caused by Aspergillus fumigatus, is responsible for a growing number of deaths among immunosuppressed patients. Immunosuppressants such as FK506 (tacrolimus) that target calcineurin have shown ... -
Contribution of urinary tract infection to the burden of febrile illnesses in young children in rural Kenya.
(PLoS One, 2017)INTRODUCTION: The clinical features of UTI in young children may not localize to the urinary tract and closely resemble other febrile illnesses. In malaria endemic areas, a child presenting with fever is often treated ... -
Do high MICs predict the outcome in invasive fusariosis?
(The Journal of antimicrobial chemotherapy, 2021-03)<h4>Background</h4>Invasive fusariosis (IF) affects mostly severely immunocompromised hosts and is associated with poor outcome. Since Fusarium species exhibit high MICs for most antifungal agents, this could explain the ... -
Drug design from the cryptic inhibitor envelope.
(Nat Commun, 2016-02-25)Conformational dynamics plays an important role in enzyme catalysis, allosteric regulation of protein functions and assembly of macromolecular complexes. Despite these well-established roles, such information has yet to ... -
Etiologies of illness among patients meeting integrated management of adolescent and adult illness district clinician manual criteria for severe infections in northern Tanzania: implications for empiric antimicrobial therapy.
(Am J Trop Med Hyg, 2015-02)We describe the laboratory-confirmed etiologies of illness among participants in a hospital-based febrile illness cohort study in northern Tanzania who retrospectively met Integrated Management of Adolescent and Adult Illness ... -
Isolation, speciation and antifungal susceptibility testing of Candida isolates from various clinical specimens at a tertiary care hospital, Nepal.
(BMC research notes, 2017-06)<h4>Background</h4>Candida species are responsible for various clinical infections ranging from mucocutaneous infection to life threatening invasive diseases along with increased resistance to antifungal drugs has made a ... -
Microbial inactivation of Pseudomonas putida and Pichia pastoris using gene silencing.
(Environ Sci Technol, 2010-05-01)Antisense deoxyoligonucleotide (ASO) gene silencing was investigated as a potential disinfection tool for industrial and drinking water treatment application. ASOs bind with their reverse complementary mRNA transcripts thereby ... -
Pediatric-specific antimicrobial susceptibility data and empiric antibiotic selection.
(Pediatrics, 2012-09)OBJECTIVE: Duke University Health System (DUHS) generates annual antibiograms combining adult and pediatric data. We hypothesized significant susceptibility differences exist for pediatric isolates and that distributing ... -
PKC signaling regulates drug resistance of the fungal pathogen Candida albicans via circuitry comprised of Mkc1, calcineurin, and Hsp90.
(PLoS Pathog, 2010-08-26)Fungal pathogens exploit diverse mechanisms to survive exposure to antifungal drugs. This poses concern given the limited number of clinically useful antifungals and the growing population of immunocompromised individuals ... -
Rare mould infections caused by Mucorales, Lomentospora prolificans and Fusarium, in San Diego, CA: the role of antifungal combination therapy.
(International journal of antimicrobial agents, 2018-11)Non-Aspergillus invasive mould infections (IMIs) are associated with devastating morbidity and mortality rates and are increasingly diagnosed in immunocompromised hosts. The aim of this study was to describe the epidemiology ... -
The inoculum effect and band-pass bacterial response to periodic antibiotic treatment.
(Mol Syst Biol, 2012)The inoculum effect (IE) refers to the decreasing efficacy of an antibiotic with increasing bacterial density. It represents a unique strategy of antibiotic tolerance and it can complicate design of effective antibiotic ... -
Voriconazole plus terbinafine combination antifungal therapy for invasive Lomentospora prolificans infections: analysis of 41 patients from the FungiScope® registry 2008-2019.
(Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2020-06)<h4>Objectives</h4>Lomentospora prolificans is an emerging cause of serious invasive fungal infections. Optimal treatment of these infections is unknown, although voriconazole-containing treatment regimens are considered ...
