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Browsing by Subject "Microglia"
Now showing items 1-18 of 18
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Anti-inflammatory effects of progesterone in lipopolysaccharide-stimulated BV-2 microglia.
(PLoS One, 2014)Female sex is associated with improved outcome in experimental brain injury models, such as traumatic brain injury, ischemic stroke, and intracerebral hemorrhage. This implies female gonadal steroids may be neuroprotective. ... -
ApoE mimetic ameliorates motor deficit and tissue damage in rat spinal cord injury.
(Journal of neuroscience research, 2014-07)Apolipoprotein E (apoE), a plasma protein responsible for transporting lipid and cholesterol, modulates responses of the central nervous system to injury. Small peptides derived from the receptor-binding region of apoE can ... -
Death and the Construction of an Astrocyte Network
(2019)Naturally-occurring cell death is a fundamental developmental mechanism for regulating cell numbers and sculpting developing organs. This is particularly true in the central nervous system, where large numbers of neurons ... -
Deferoxamine regulates neuroinflammation and iron homeostasis in a mouse model of postoperative cognitive dysfunction.
(J Neuroinflammation, 2016-10-12)BACKGROUND: Postoperative cognitive dysfunction (POCD) is a common complication after surgery, especially amongst elderly patients. Neuroinflammation and iron homeostasis are key hallmarks of several neurological disorders. ... -
Female gonadal hormone effects on microglial activation and functional outcomes in a mouse model of moderate traumatic brain injury.
(World J Crit Care Med, 2017-05-04)AIM: To address the hypothesis that young, gonad-intact female mice have improved long-term recovery associated with decreased neuroinflammation compared to male mice. METHODS: Eight to ten week-old male, female, ... -
Human umbilical cord blood monocytes, but not adult blood monocytes, rescue brain cells from hypoxic-ischemic injury: Mechanistic and therapeutic implications.
(PloS one, 2019-01)Cord blood (CB) mononuclear cells (MNC) are being tested in clinical trials to treat hypoxic-ischemic (HI) brain injuries. Although early results are encouraging, mechanisms underlying potential clinical benefits are not ... -
Hybrid Brain-Tissue Based Model to Study the Role of Infiltrating Monocytes in Late Stage Huntington's Disease
(2019)Huntington’s Disease (HD) is an inherited, progressive, fatal, and late-onset neurodegenerative disorder. Its neuropathogenesis is characterized by selective loss of medium spiny neurons (MSNs) in the striatum and cortical ... -
Mefenamic acid can attenuate depressive symptoms by suppressing microglia activation induced upon chronic stress.
(Brain research, 2020-08)BACKGROUND:Depression is the most debilitating neuropsychiatric disorder, and psychosocial stressors are major risk factors for the onset of depression. Depression is closely associated with chronic inflammation and microglia ... -
Microglia are effector cells of CD47-SIRPα antiphagocytic axis disruption against glioblastoma.
(Proceedings of the National Academy of Sciences of the United States of America, 2019-01)Glioblastoma multiforme (GBM) is a highly aggressive malignant brain tumor with fatal outcome. Tumor-associated macrophages and microglia (TAMs) have been found to be major tumor-promoting immune cells in the tumor ... -
Molecular mechanisms underlying retinal astrocyte death during development
(2023)Developmental cell death is essential for nervous system development, sculpting the developing tissue by controlling cell numbers. While developmental neuron death has been studied extensively, the most abundant cell type ... -
Neuroimmune and Developmental Mechanisms Regulating Motivational Behaviors for Opioids
(2016)Opioid drug abuse represents a serious public health concern with few effective therapeutic strategies. A primary goal for researchers modeling substance abuse disorders has been the delineation of the biological ... -
Polio Virotherapy of Malignant Glioma Engages the Tumor Myeloid Infiltrate and Triggers Global Microglia Activation
(2022)Malignant glioma formation involves an abundant inflammatory infiltrate dominated by glioma-associated macrophages and microglia (GAMM). GAMM constitutes a large portion of the glioma mass and tumor microenvironment. They ... -
Regulation of Integrin α6 Recycling by Calcium-independent Phospholipase A2 (iPLA2) to Promote Microglia Chemotaxis on Laminin.
(The Journal of biological chemistry, 2016-11)Microglia are the immune effector cells that are activated in response to pathological changes in the central nervous system. Microglial activation is accompanied by the alteration of integrin expression on the microglia ... -
Retinal pigment epithelium and microglia express the CD5 antigen-like protein, a novel autoantigen in age-related macular degeneration.
(Experimental eye research, 2017-02)We report on a novel autoantigen expressed in human macular tissues, identified following an initial Western blot (WB)-based screening of sera from subjects with age-related macular degeneration (AMD) for circulating ... -
Role of iPLA(2) in the regulation of Src trafficking and microglia chemotaxis.
(Traffic (Copenhagen, Denmark), 2011-07)Microglia are immune effector cells in the central nervous system (CNS) and their activation, migration and proliferation play crucial roles in brain injuries and diseases. We examined the role of intracellular ... -
Signaling Pathways Controlling Microglia Chemotaxis.
(Molecules and cells, 2017-03-17)Microglia are the primary resident immune cells of the central nervous system (CNS). They are the first line of defense of the brain's innate immune response against infection, injury, and diseases. Microglia respond to ... -
Single-cell transcriptomic analysis of the immune cell landscape in the aged mouse brain after ischemic stroke.
(Journal of neuroinflammation, 2022-04-07)<h4>Background</h4>Ischemic stroke is a medical emergency that primarily affects the elderly. A complex immune response in the post-stroke brain constitutes a key component of stroke pathophysiology. This study aimed to ... -
β-arrestin 2-dependent activation of ERK1/2 is required for ADP-induced paxillin phosphorylation at Ser(83) and microglia chemotaxis.
(Glia, 2012-09)Microglia play crucial roles in increased inflammation in the central nervous system upon brain injuries and diseases. Extracellular ADP has been reported to induce microglia chemotaxis and membrane ruffle formation through ...
