Browsing by Subject "Microtubule-Associated Proteins"
Now showing items 1-7 of 7
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Autophagy enhances NFκB activity in specific tissue macrophages by sequestering A20 to boost antifungal immunity.
(Nat Commun, 2015-01-22)Immune responses must be well restrained in a steady state to avoid excessive inflammation. However, such restraints are quickly removed to exert antimicrobial responses. Here we report a role of autophagy in an early host ... -
Consensus nomenclature for the human ArfGAP domain-containing proteins.
(J Cell Biol, 2008-09-22)At the FASEB summer research conference on "Arf Family GTPases", held in Il Ciocco, Italy in June, 2007, it became evident to researchers that our understanding of the family of Arf GTPase activating proteins (ArfGAPs) has ... -
Cytokinesis proteins Tum and Pav have a nuclear role in Wnt regulation.
(J Cell Sci, 2010-07-01)Wg/Wnt signals specify cell fates in both invertebrate and vertebrate embryos and maintain stem-cell populations in many adult tissues. Deregulation of the Wnt pathway can transform cells to a proliferative fate, leading ... -
Growth factor erv1-like modulates Drp1 to preserve mitochondrial dynamics and function in mouse embryonic stem cells.
(Mol Biol Cell, 2010-04-01)The relationship of mitochondrial dynamics and function to pluripotency are rather poorly understood aspects of stem cell biology. Here we show that growth factor erv1-like (Gfer) is involved in preserving mouse embryonic ... -
How the kinetochore couples microtubule force and centromere stretch to move chromosomes.
(Nature cell biology, 2016-04)The Ndc80 complex (Ndc80, Nuf2, Spc24 and Spc25) is a highly conserved kinetochore protein essential for end-on anchorage to spindle microtubule plus ends and for force generation coupled to plus-end polymerization ... -
The exon junction complex component Magoh controls brain size by regulating neural stem cell division.
(Nat Neurosci, 2010-05)Brain structure and size require precise division of neural stem cells (NSCs), which self-renew and generate intermediate neural progenitors (INPs) and neurons. The factors that regulate NSCs remain poorly understood, and ... -
VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD.
(Autophagy, 2010-02)VCP (VCP/p97) is a ubiquitously expressed member of the AAA(+)-ATPase family of chaperone-like proteins that regulates numerous cellular processes including chromatin decondensation, homotypic membrane fusion and ...
