Now showing items 1-20 of 26

    • A Diffusion MRI Tractography Connectome of the Mouse Brain and Comparison with Neuronal Tracer Data. 

      Badea, Alexandra; Calabrese, Evan; Cofer, Gary P; Johnson, G Allan; Qi, Y (Cereb Cortex, 2015-11)
      Interest in structural brain connectivity has grown with the understanding that abnormal neural connections may play a role in neurologic and psychiatric diseases. Small animal connectivity mapping techniques are particularly ...
    • A framework for integrating the songbird brain. 

      Carninci, P; Dietrich, F; Hartemink, Alexander J; Hayashizaki, Y; Jarvis, Erich David; Lin, S; McConnell, P; ... (15 authors) (J Comp Physiol A Neuroethol Sens Neural Behav Physiol, 2002-12)
      Biological systems by default involve complex components with complex relationships. To decipher how biological systems work, we assume that one needs to integrate information over multiple levels of complexity. The songbird ...
    • A Refined Neuronal Population Measure of Visual Attention. 

      Mayo, Patrick; Cohen, Marlene R; Maunsell, John HR (PloS one, 2015-01)
      Neurophysiological studies of cognitive mechanisms such as visual attention typically ignore trial-by-trial variability and instead report mean differences averaged across many trials. Advances in electrophysiology allow ...
    • A Three-Threshold Learning Rule Approaches the Maximal Capacity of Recurrent Neural Networks. 

      Alemi, A; Baldassi, C; Brunel, Nicolas; Zecchina, R (PLoS Comput Biol, 2015-08)
      Understanding the theoretical foundations of how memories are encoded and retrieved in neural populations is a central challenge in neuroscience. A popular theoretical scenario for modeling memory function is the attractor ...
    • Chaos in percepts? 

      Richards, W; Sommer, Marc A; Wilson, HR (Biol Cybern, 1994)
      Multistability in perceptual tasks has suggested that the mechanisms underlying our percepts might be modeled as nonlinear, deterministic systems that exhibit chaotic behavior. We present evidence supporting this view, obtaining ...
    • Coherence potentials: loss-less, all-or-none network events in the cortex. 

      Lebedev, Mikhail A; Nicolelis, Miguel A; Plenz, D; Thiagarajan, TC (PLoS Biol, 2010-01-12)
      Transient associations among neurons are thought to underlie memory and behavior. However, little is known about how such associations occur or how they can be identified. Here we recorded ongoing local field potential (LFP) ...
    • Computational inference of neural information flow networks. 

      Hartemink, Alexander J; Jarvis, Erich David; Smith, VA; Smulders, TV; Yu, J (PLoS Comput Biol, 2006-11-24)
      Determining how information flows along anatomical brain pathways is a fundamental requirement for understanding how animals perceive their environments, learn, and behave. Attempts to reveal such neural information flow ...
    • Cross-modal stimulus conflict: the behavioral effects of stimulus input timing in a visual-auditory Stroop task. 

      Appelbaum, Lawrence Gregory; Donohue, Sarah; Park, CJ; Roberts, K; Woldorff, Marty G (PLoS One, 2013)
      Cross-modal processing depends strongly on the compatibility between different sensory inputs, the relative timing of their arrival to brain processing components, and on how attention is allocated. In this behavioral study, ...
    • Differential developmental trajectories of magnetic susceptibility in human brain gray and white matter over the lifespan. 

      Bancroft-Wu, V; Batrachenko, A; De Bellis, MD; Langkammer, C; Li, W; Liu, C; Morey, Rajendra A; ... (11 authors) (Hum Brain Mapp, 2014-06)
      As indicated by several recent studies, magnetic susceptibility of the brain is influenced mainly by myelin in the white matter and by iron deposits in the deep nuclei. Myelination and iron deposition in the brain evolve ...
    • Dynamics of visual receptive fields in the macaque frontal eye field. 

      DiTomasso, AR; Mayo, J Patrick; Smith, MA; Sommer, Marc A (J Neurophysiol, 2015-12)
      Neuronal receptive fields (RFs) provide the foundation for understanding systems-level sensory processing. In early visual areas, investigators have mapped RFs in detail using stochastic stimuli and sophisticated analytical ...
    • Efficient coding of spatial information in the primate retina. 

      Field, Greg; Doi, Eizaburo; Gauthier, Jeffrey L; Shlens, Jonathon; Sher, Alexander; Greschner, Martin; Machado, Timothy A; ... (14 authors) (The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012-11)
      Sensory neurons have been hypothesized to efficiently encode signals from the natural environment subject to resource constraints. The predictions of this efficient coding hypothesis regarding the spatial filtering properties ...
    • Enhancing the Hodgkin-Huxley Equations: Simulations Based on the First Publication in the Biophysical Journal. 

      Moore, JW (Biophys J, 2015-10-06)
      The experiments in the Cole and Moore article in the first issue of the Biophysical Journal provided the first independent experimental confirmation of the Hodgkin-Huxley (HH) equations. A log-log plot of the K current versus ...
    • Evaluating functional network inference using simulations of complex biological systems. 

      Hartemink, Alexander J; Jarvis, Erich David; Smith, VA (Bioinformatics, 2002)
      MOTIVATION: Although many network inference algorithms have been presented in the bioinformatics literature, no suitable approach has been formulated for evaluating their effectiveness at recovering models of complex biological ...
    • Exercise-induced pain intensity predicted by pre-exercise fear of pain and pain sensitivity. 

      Bishop, Mark D; George, Steven Z; Horn, Maggie Elizabeth (Clin J Pain, 2011-06)
      OBJECTIVES: Our primary goals were to determine whether preexisting fear of pain and pain sensitivity contributed to post-exercise pain intensity. METHODS: Delayed-onset muscle pain was induced in the trunk extensors of ...
    • Functional connectivity in the retina at the resolution of photoreceptors. 

      Field, Greg; Gauthier, Jeffrey L; Sher, Alexander; Greschner, Martin; Machado, Timothy A; Jepson, Lauren H; Shlens, Jonathon; ... (13 authors) (Nature, 2010-10)
      To understand a neural circuit requires knowledge of its connectivity. Here we report measurements of functional connectivity between the input and ouput layers of the macaque retina at single-cell resolution and the implications ...
    • Learned birdsong and the neurobiology of human language. 

      Jarvis, Erich David (Ann N Y Acad Sci, 2004-06)
      Vocal learning, the substrate for human language, is a rare trait found to date in only three distantly related groups of mammals (humans, bats, and cetaceans) and three distantly related groups of birds (parrots, hummingbirds, ...
    • Mapping nonlinear receptive field structure in primate retina at single cone resolution. 

      Field, Greg; Freeman, Jeremy; Li, Peter H; Greschner, Martin; Gunning, Deborah E; Mathieson, Keith; Sher, Alexander; ... (11 authors) (eLife, 2015-10-30)
      The function of a neural circuit is shaped by the computations performed by its interneurons, which in many cases are not easily accessible to experimental investigation. Here, we elucidate the transformation of visual signals ...
    • Memory capacity of networks with stochastic binary synapses. 

      Dubreuil, AM; Amit, Y; Brunel, Nicolas (PLoS Comput Biol, 2014-08)
      In standard attractor neural network models, specific patterns of activity are stored in the synaptic matrix, so that they become fixed point attractors of the network dynamics. The storage capacity of such networks has ...
    • Memory maintenance in synapses with calcium-based plasticity in the presence of background activity. 

      Brunel, Nicolas; Graupner, M; Higgins, David (PLoS Comput Biol, 2014-10)
      Most models of learning and memory assume that memories are maintained in neuronal circuits by persistent synaptic modifications induced by specific patterns of pre- and postsynaptic activity. For this scenario to be viable, ...
    • Modulation of network excitability by persistent activity: how working memory affects the response to incoming stimuli. 

      Tartaglia, EM; Brunel, Nicolas; Mongillo, G (PLoS Comput Biol, 2015-02)
      Persistent activity and match effects are widely regarded as neuronal correlates of short-term storage and manipulation of information, with the first serving active maintenance and the latter supporting the comparison between ...