Browsing by Subject "Models, Statistical"
Now showing items 1-20 of 54
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29 mammalian genomes reveal novel exaptations of mobile elements for likely regulatory functions in the human genome.
(PloS one, 2012-01)Recent research supports the view that changes in gene regulation, as opposed to changes in the genes themselves, play a significant role in morphological evolution. Gene regulation is largely dependent on transcription ... -
A functional analysis of the spacer of V(D)J recombination signal sequences.
(PLoS Biol, 2003-10)During lymphocyte development, V(D)J recombination assembles antigen receptor genes from component V, D, and J gene segments. These gene segments are flanked by a recombination signal sequence (RSS), which serves as the ... -
Advances to Bayesian network inference for generating causal networks from observational biological data.
(Bioinformatics, 2004-12-12)MOTIVATION: Network inference algorithms are powerful computational tools for identifying putative causal interactions among variables from observational data. Bayesian network inference algorithms hold particular promise ... -
An age-structured extension to the vectorial capacity model.
(PLoS One, 2012)BACKGROUND: Vectorial capacity and the basic reproductive number (R(0)) have been instrumental in structuring thinking about vector-borne pathogen transmission and how best to prevent the diseases they cause. One of the ... -
An approach to the development of quantitative models to assess the effects of exposure to environmentally relevant levels of endocrine disruptors on homeostasis in adults.
(Environmental health perspectives, 1999-08)The workshop "Characterizing the Effects of Endocrine Disruptors on Human Health at Environmental Exposure Levels" was held to provide a forum for discussions and recommendations of methods and data needed to improve risk ... -
Are prediction models for vaginal birth after cesarean accurate?
(American journal of obstetrics and gynecology, 2019-05)BACKGROUND:The use of trial of labor after cesarean delivery calculators in the prediction of successful vaginal birth after cesarean delivery gives physicians an evidence-based tool to assist with patient counseling and ... -
Association between DNA damage response and repair genes and risk of invasive serous ovarian cancer.
(PLoS One, 2010-04-08)BACKGROUND: We analyzed the association between 53 genes related to DNA repair and p53-mediated damage response and serous ovarian cancer risk using case-control data from the North Carolina Ovarian Cancer Study (NCOCS), ... -
Automated quality control in nuclear medicine using the structured noise index.
(Journal of applied clinical medical physics, 2020-04)<h4>Purpose</h4>Daily flood-field uniformity evaluation serves as the central element of nuclear medicine (NM) quality control (QC) programs. Uniformity images are traditionally analyzed using pixel value-based metrics, ... -
Calcium-based plasticity model explains sensitivity of synaptic changes to spike pattern, rate, and dendritic location.
(Proceedings of the National Academy of Sciences of the United States of America, 2012-03)Multiple stimulation protocols have been found to be effective in changing synaptic efficacy by inducing long-term potentiation or depression. In many of those protocols, increases in postsynaptic calcium concentration have ... -
Cervical cancer precursors and hormonal contraceptive use in HIV-positive women: application of a causal model and semi-parametric estimation methods.
(PLoS One, 2014)OBJECTIVE: To demonstrate the application of causal inference methods to observational data in the obstetrics and gynecology field, particularly causal modeling and semi-parametric estimation. BACKGROUND: Human immunodeficiency ... -
Childhood bullying involvement predicts low-grade systemic inflammation into adulthood.
(Proc Natl Acad Sci U S A, 2014-05-27)Bullying is a common childhood experience that involves repeated mistreatment to improve or maintain one's status. Victims display long-term social, psychological, and health consequences, whereas bullies display minimal ... -
Compressive holography.
(2012)Compressive holography estimates images from incomplete data by using sparsity priors. Compressive holography combines digital holography and compressive sensing. Digital holography consists of computational image estimation ... -
Computed tomography dose index and dose length product for cone-beam CT: Monte Carlo simulations.
(Journal of applied clinical medical physics, 2011-01-19)Dosimetry in kilovoltage cone beam computed tomography (CBCT) is a challenge due to the limitation of physical measurements. To address this, we used a Monte Carlo (MC) method to estimate the CT dose index (CTDI) and the ... -
Cytokine profiles of preterm neonates with fungal and bacterial sepsis.
(Pediatr Res, 2012-08)BACKGROUND: Information on cytokine profiles in fungal sepsis (FS), an important cause of mortality in extremely low birthweight (ELBW) infants, is lacking. We hypothesized that cytokine profiles in the first 21 d of life ... -
Designing risk prediction models for ambulatory no-shows across different specialties and clinics.
(Journal of the American Medical Informatics Association : JAMIA, 2018-08)Objective:As available data increases, so does the opportunity to develop risk scores on more refined patient populations. In this paper we assessed the ability to derive a risk score for a patient no-showing to a clinic ... -
Development and Validation of a Model for Opioid Prescribing Following Gynecological Surgery.
(JAMA network open, 2022-07)<h4>Importance</h4>Overprescription of opioid medications following surgery is well documented. Current prescribing models have been proposed in narrow patient populations, which limits their generalizability.<h4>Objective</h4>To ... -
Enhancing imaging systems using transformation optics.
(Opt Express, 2010-09-27)We apply the transformation optical technique to modify or improve conventional refractive and gradient index optical imaging devices. In particular, when it is known that a detector will terminate the paths of rays over ... -
Equity and accuracy in medical malpractice insurance pricing.
(J Health Econ, 1990-11)This study examines alternative classification approaches for setting medical malpractice insurance premiums. Insurers generally form risk classification categories on factors other than the physician's own loss experience. ... -
Estimating the Impacts of Local Policy Innovation: The Synthetic Control Method Applied to Tropical Deforestation.
(PLoS One, 2015)Quasi-experimental methods increasingly are used to evaluate the impacts of conservation interventions by generating credible estimates of counterfactual baselines. These methods generally require large samples for statistical ... -
Estimation and validation of a multiattribute model of Alzheimer disease progression.
(Med Decis Making, 2010-11)OBJECTIVES: To estimate and validate a multiattribute model of the clinical course of Alzheimer disease (AD) from mild AD to death in a high-quality prospective cohort study, and to estimate the impact of hypothetical ...
