Browsing by Subject "Molecular Biology"
Now showing items 1-20 of 25
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apex: phylogenetics with multiple genes.
(Mol Ecol Resour, 2017-01)Genetic sequences of multiple genes are becoming increasingly common for a wide range of organisms including viruses, bacteria and eukaryotes. While such data may sometimes be treated as a single locus, in practice, a number ... -
Autophagy in Metabolism, Cell Death, and Leukemogenesis
(2011)Tissue homeostasis is controlled by the availability of growth factors, which sustain exogenous nutrient uptake and prevent apoptosis. Cancer cells, however, can express constitutively active oncogenic kinases such as BCR-Abl ... -
Auxiliary Wnt3A Signaling in Cell Fate Decisions of C3H10T1/2 Mesenchymal Stem Cells
(2011)Activation of Wnt signaling pathways is critical to a variety of developmental events across all animal taxa. These highly evolutionarily conserved pathways are also important in the adult organism for maintaining homeostasis ... -
CaMKK2 Contributes to the Regulation of Energy Balance
(2011)The incidence of obesity and associated diseases such as type 2-diabetes and hypertension has reached epidemic portions worldwide and attracted increased interest to understand the mechanisms that are responsible for these ... -
Chapter 1 - Tubular liposomes with variable permeability for reconstitution of FtsZ rings.
(Methods in enzymology, 2009-01)We have developed a system for producing tubular multilamellar liposomes that incorporate the protein FtsZ on the inside. We start with a mixture of spherical multilamellar liposomes with FtsZ initially on the outside. Shearing ... -
Chromatin Determinants of the Eukaryotic DNA Replication Program
(2011)The accurate and timely replication of eukaryotic DNA during S-phase is of critical importance for the cell and for the inheritance of genetic information. Missteps in the replication program can activate cell cycle checkpoints ... -
eIF4E Phosphorylation Balances Cap-dependent and Cap-independent Translation Initiation
(2011)Signaling pathways converge on the translation machinery and influence protein synthesis globally or specifically on certain classes of transcripts. The experiments described in this thesis focus on regulation of translation ... -
Exploring the Immunogenicity and Therapeutic Applications of Boranophosphate-modified RNA: siRNA and RNA Aptamers
(2011)Borane (BH<sub>3<sub>) chemistry offers unique chemical characteristics that enable boranophosphate (BP) oligonucleotides with potential to enhance RNA therapeutic applications such as RNA interference (RNAi) and RNA aptamers. ... -
Glucose metabolism and p53 in leukemia
(2011)Healthy cells require input from growth factor signaling pathways to maintain cell metabolism and survival. Growth factor deprivation induces a loss of glucose metabolism that contributes to cell death in this context, ... -
Identification of Novel Regulators in Hematopoiesis: Roles for Gfer in Hematopoietic Stem Cell Proliferation and CaMKK2 in the Restriction of Granulopoiesis
(2011)<p>Hematopoiesis is the process in which billions of blood cells are produced on a daily basis, and is vital for sustaining life. This process is tightly regulated by a dynamic balance between hematopoietic stem cell (HSC) ... -
Interactions of a secreted Pseudomonas aeruginosa aminopeptidase with bacterial outer membrane molecules: characterization and implications for bacterial pathogenic phenotypes.
(2017-05-08)The protein Pseudomonas aeruginosa aminopeptidase (PaAP) is secreted by the opportunistic, Gram-negative bacterial pathogen Pseudomonas aeruginosa. PaAP expression appears to be upregulated in clinical isolates of P. aeruginosa, ... -
Investigating the Roles of Tat Specific Factor 1 in Both HIV-1 and Cellular Gene Expression
(2009)HIV-1 relies on both viral and cellular host factors for expression of its genome. Tat specific factor 1 (Tat-SF1) was identified as a cellular cofactor required for enhanced transcription of HIV-1 <italic>in vitro</italic>. ... -
Investigation of Chondroprotective Mechanisms of Selenium
(2010)Selenium (Se) is an essential trace element and metalloid involved in several key metabolic activities: protection against oxidative damage, regulation of immune and thyroid function, and fertility. Several recent lines ... -
Mechanisms of Eukaryotic Copper Homeostasis
(2010)Copper (Cu) is a co-factor that is essential for oxidative phosphorylation, protection from oxidative stress, angiogenesis, signaling, iron acquisition, peptide hormone maturation, and a number of other cellular processes. ... -
Metabolic Regulation of Caspase-2
(2011)Apoptosis is a form of programmed cellular "suicide" which is activated in response to a variety of pro-death stimuli. Apoptotic cell death is orderly and energy-dependent, and cellular constituents are packaged ... -
Neuronal and Molecular Basis of Nociception and Thermosensation in Drosophila melanogaster
(2011)From insects to mammals, the ability to constantly sense environmental stimuli is essential for the survival of most living organisms. Most animals have nocifensive behaviors towards extreme temperatures, mechanical stimuli ... -
Principles of HuR-RNA targeting, interaction dynamics, and functional outcomes
(2010)In recent years, the pervasiveness and importance of post-transcriptional regulation has reshaped the underlying principles of the organizational logic of gene expression. RNA-binding proteins (RBPs) and non-coding RNAs ... -
Regulation of CaMKKβ Dependent Signaling Pathways
(2011)Ca<super>2+</super>/Calmodulin-dependent protein kinase kinase β(CaMKKβ) is a serine/threonine directed kinase which is activated following increases in intracellular Ca<super>2+</super>. CaMKKβ activates ... -
RNA Recognition and Regulation of the AU-rich RNA Binding Proteins: HuR, TTP and BRF1
(2011)Posttranscriptional gene expression is controlled and coordinated by RNA binding proteins (RBPs), many of which recognize specific RNAs through cis-regulatory RNA elements. One of the most highly studied classes ... -
SR proteins in microRNA/mRNA biogenesis
(2011)SR proteins are a family of splicing factors involved in the regulation of both constitutive and alternative splicing of pre-mRNAs. Despite years of studies, several big questions still remain: how the expression levels ...
