Now showing items 1-9 of 9

    • A chemical method for labeling lysine methyltransferase substrates. 

      Binda, Olivier; Boyce, Michael; Rush, Jason S; Palaniappan, Krishnan K; Bertozzi, Carolyn R; Gozani, Or (Chembiochem : a European journal of chemical biology, 2011-01)
      Several protein lysine methyltransferases (PKMTs) modify histones to regulate chromatin-dependent cellular processes, such as transcription, DNA replication and DNA damage repair. PKMTs are likely to have many additional ...
    • Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. 

      Degterev, Alexei; Huang, Zhihong; Boyce, Michael; Li, Yaqiao; Jagtap, Prakash; Mizushima, Noboru; Cuny, Gregory D; ... (10 authors) (Nature chemical biology, 2005-07)
      The mechanism of apoptosis has been extensively characterized over the past decade, but little is known about alternative forms of regulated cell death. Although stimulation of the Fas/TNFR receptor family triggers a canonical ...
    • Conductive junctions with parallel graphene sheets. 

      Zheng, Xiao; Ke, San-Huang; Yang, Weitao (J Chem Phys, 2010-03-21)
      The establishment of conductive graphene-molecule-graphene junction is investigated through first-principles electronic structure calculations and quantum transport calculations. The junction consists of a conjugated molecule ...
    • Identification of select glucocorticoids as Smoothened agonists: potential utility for regenerative medicine. 

      Wang, Jiangbo; Lu, Jiuyi; Bond, Michael C; Chen, Minyong; Ren, Xiu-Rong; Lyerly, H Kim; Barak, Larry S; ... (8 authors) (Proc Natl Acad Sci U S A, 2010-05-18)
      Regenerative medicine holds the promise of replacing damaged tissues largely by stem cell activation. Hedgehog signaling through the plasma membrane receptor Smoothened (Smo) is an important process for regulating stem cell ...
    • Modulating unimolecular charge transfer by exciting bridge vibrations. 

      Lin, Zhiwei; Lawrence, Candace M; Xiao, Dequan; Kireev, Victor V; Skourtis, Spiros S; Sessler, Jonathan L; Beratan, David N; ... (8 authors) (J Am Chem Soc, 2009-12-23)
      Ultrafast UV-vibrational spectroscopy was used to investigate how vibrational excitation of the bridge changes photoinduced electron transfer between donor (dimethylaniline) and acceptor (anthracene) moieties bridged by ...
    • Multivalent benzoboroxole functionalized polymers as gp120 glycan targeted microbicide entry inhibitors. 

      Jay, Julie I; Lai, Bonnie E; Myszka, David G; Mahalingam, Alamelu; Langheinrich, Kris; Katz, David F; Kiser, Patrick F (Mol Pharm, 2010-02-01)
      Microbicides are women-controlled prophylactics for sexually transmitted infections. The most important class of microbicides target HIV-1 and contain antiviral agents formulated for topical vaginal delivery. Identification ...
    • Reductive ligation mediated one-step disulfide formation of S-nitrosothiols. 

      Zhang, Jiming; Li, Sheng; Zhang, Dehui; Wang, Hua; Whorton, A Richard; Xian, Ming (Org Lett, 2010-09-17)
      A one-step reductive ligation mediated disulfide formation of S-nitrosothiols was developed. This reaction involves the reaction of the S-nitroso group with phosphine-thioesters to form sulfenamide and thiolate intermediates, ...
    • The manganese(III) porphyrin MnTnHex-2-PyP5+ modulates intracellular ROS and breast cancer cell migration: Impact on doxorubicin-treated cells. 

      Flórido, Ana; Saraiva, Nuno; Cerqueira, Sara; Almeida, Nuno; Parsons, Maddy; Batinic-Haberle, Ines; Miranda, Joana P; ... (12 authors) (Redox biology, 2019-01)
      Manganese(III) porphyrins (MnPs) are superoxide dismutase (SOD) mimics with demonstrated beneficial effects in cancer treatment in combination with chemo- and radiotherapy regimens. Despite the ongoing clinical trials, little ...
    • Total synthesis of cyanolide A and confirmation of its absolute configuration. 

      Kim, Hyoungsu; Hong, Jiyong (Org Lett, 2010-06-18)
      The tandem allylic oxidation/oxa-Michael reaction promoted by the gem-disubstituent effect and the 2-methyl-6-nitrobenzoic anhydride (MNBA)-mediated dimerization were explored for the efficient and facile synthesis of cyanolide ...