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Browsing by Subject "Molecular biology"
Now showing items 1-20 of 229
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A Central Role for Hypoxia-inducible Transcription Factor Signaling in the Regulation of Skeletal Lineage Cells
(2022)Osteoporosis and low bone density affect an estimated 54 million adults of 50 years and over in the United States, resulting in $19 billion in costs for osteoporosis-related bone breaks. Current treatments include the use ... -
A Genome-Wide RNAi Screen Identifies CDC-42 and GDI-1 as In Vivo Regulators of Invadopodia
(2015)Basement membrane (BM) is a sheet-like extracellular matrix that underlies most tissues and acts as a barrier to invading cells. Many cell types, including immune cells, cells migrating during development and morphogenesis, ... -
A Role for Cytoplasmic 3'-Nucleotide Hydrolysis in Liver and Intestine Function
(2012)Bisphosphate 3'-nucleotidase (Bpnt1) is a member of a family of small molecule phosphatases whose activities depend on divalent cations and are inhibited by lithium. While the enzymes share many commonalities, they have ... -
A Role for Gic1 and Gic2 in Promoting Cdc42 Polarization
(2018)The Rho GTPase Cdc42 is a master regulator of cell polarity that orchestrates reorganization of the cytoskeleton. During polarity establishment, active GTP-Cdc42 accumulates at a part of the cell cortex that becomes the ... -
Abl Family Kinases Regulate Endothelial Function
(2013)The vasculature has a crucial function in normal physiology, enabling the transport of oxygen and nutrients to cells throughout the body. In turn, endothelial cells, which form the inner-most lining of blood vessels, are ... -
Achieving Cell-Specific Delivery of Multiple Oligonucleotide Therapeutics with Aptamer Chimeras
(2012)Current standard cancer treatments such as chemotherapeutics, and radiation therapy are nearly as likely to kill the patient as cure the cancer. Therapies that have such a narrow window of efficacy are necessary for the ... -
Aminopeptidase-Dependent Modulation of Bacterial Biofilms by Pseudomonas aeruginosa Outer Membrane Vesicles
(2019)Pseudomonas aeruginosa, known as one of the leading causes of morbidity and mortality in cystic fibrosis (CF) patients, secretes a variety of virulence-associated proteases. These enzymes have been shown to contribute ... -
Antineoplastic Cytotoxicity and Immune Adjuvancy of a Recombinant Oncolytic Poliovirus
(2016)Our group has pioneered the development of a live-attenuated poliovirus, called PVSRIPO, for the purpose of targeting cancer. Despite clinical progress, the cancer selective cytotoxicity and immunotherapeutic potential of ... -
APOBEC Mutagenesis as a Driver of Tumor Evolution through Genetic Heterogeneity and Immunogenicity
(2021)The APOBEC (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like) family of cytidine deaminases is one of the most common endogenous sources of single base substitution mutations in human cancer. Accordingly, ... -
Application of Repetitive Protein Polypeptides with an Upper Critical Solution Temperature at Various Length Scales
(2019)Phase separation of macromolecules is a critical phenomenon for the human condition. This phenomenon has also been exploited for biotechnological development to improve human morbidity and mortality. However, there is ... -
Bioinformatics and Molecular Approaches for the Construction of Biological Artificial Cartilage
(2018)Osteoarthritis (OA) is one of the leading causes of disability in the United States, afflicting over 27 million Americans and imposing an economic burden of more than $128 billion each year (1, 2). OA is characterized by ... -
Bone Morphogenetic Proteins Signal through Smad1/5/8 to induce MET, Smad2 to Specify the Dorsoventral Axis and Smad3 to Facilitate Invasion.
(2013)The bone morphogenetic protein (BMP) signaling pathways have important roles in embryonic development and homeostasis. BMPs have been shown to pattern the dorsoventral axis in zebrafish (<italic>Danio rerio</italic>) early ... -
Broad Remodeling of the Acetylproteome by SIRT3 Manipulation Fails to Affect Insulin Secretion or β-cell Metabolism in the Absence of Dietary Overnutrition
(2018)SIRT3 is an NAD+-dependent mitochondrial protein deacetylase purported to influence cellular and systemic metabolism through modulation of the mitochondrial acetylproteome. Fuel-stimulated insulin secretion from pancreatic ... -
Ca2+-Mediated Thermal Sensing in Plants
(2017)Temperature is an omnipresent environmental factor that shapes the growth, development and survival of plants. However, global warming has been an inevitable process and caused unusual temperature patterns across the world. ... -
Cell Wall Lipids Promoting Host Angiogenesis During Mycobacterial Infection
(2018)Mycobacterial infection leads to the formation of characteristic immune cell aggregates called granulomas. In humans and animal models, tuberculous granuloma formation is accompanied by dramatic remodeling of host vasculature ... -
Cell-cycle Dependent Regulation of Telomere-Associate Proteins
(2013)Telomeres are protein-DNA structures at the ends of eukaryotic chromosomes. The DNA portion is comprised of double-stranded and single-stranded G-rich repetitive DNA. The protein portion is anchored by the "shelterin complex" ... -
Cellular and Molecular Mechanisms of Retinal Neuron Spatial Patterning
(2019)During development, cell-cell recognition events mediate crucial steps in the formation of organized cellular patterns critical for tissue function. In the nervous system, cell recognition cues guide migrating neurons during ... -
Cellular Coordinators: Mechanisms by Which Non-Enzymatic Proteins Contribute to Growth and Cell Surface Remodeling in the Human Fungal Pathogen Cryptococcus neoformans
(2022)My thesis work has focused on characterizing mechanisms by which human fungal pathogens regulate their adaptive cellular responses in order to survive and cause disease in the human host. Unlike most microbial fungi found ... -
Cellular Reprogramming in Response to Viral Infection and Oncogenic Transformation
(2021)In this dissertation, I reported several cellular reprogramming mechanisms in response to different factors, such as viral infection and oncogenic transformation, by utilizing molecular biology and high-throughput sequencing ... -
Cerebral Cavernous Malformations: From Two-Hit Mechanism to Developing a Targeted Therapy
(2013)Cerebral cavernous malformations (CCMs) are multicavernous vascular lesions affecting the central nervous system. Affected individuals have a lifetime risk of recurrent headaches, focal neurological deficits, seizures, ...
