Now showing items 1-5 of 5

    • De novo design and molecular assembly of a transmembrane diporphyrin-binding protein complex. 

      Blasie, JK; Degrado, WF; Fry, HC; Kim, YH; Korendovych, IV; Lear, JD; Senes, A; ... (9 authors) (J Am Chem Soc, 2010-11-10)
      The de novo design of membrane proteins remains difficult despite recent advances in understanding the factors that drive membrane protein folding and association. We have designed a membrane protein PRIME (PoRphyrins In ...
    • Dynamics of PTH-induced disassembly of Npt2a/NHERF-1 complexes in living OK cells. 

      Blanpied, Thomas A; Shenolikar, Shirish; Steplock, Deborah; Weinman, Edward J (American journal of physiology. Renal physiology, 2011-01)
      Parathyroid hormone (PTH) inhibits the reabsorption of phosphate in the renal proximal tubule by disrupting the binding of the sodium-dependent phosphate transporter 2A (Npt2a) to the adapter protein sodium-hydrogen exchanger ...
    • FtsZ Protofilament Curvature Is the Opposite of Tubulin Rings. 

      Erickson, Harold Paul; Housman, Max; Milam, Sara L; Moore, Desmond A; Osawa, Masaki (Biochemistry, 2016-07)
      FtsZ protofilaments (pfs) form the bacterial cytokinetic Z ring. Previous work suggested that a conformational change from straight to curved pfs generated the constriction force. In the simplest model, the C-terminal membrane ...
    • The bromodomain protein Brd4 insulates chromatin from DNA damage signalling. 

      Blake, EJ; Bradner, JE; Bryson, BD; Cannell, IG; Carpenter, AE; Chen, CC; Chen, GC; ... (24 authors) (Nature, 2013-06-13)
      DNA damage activates a signalling network that blocks cell-cycle progression, recruits DNA repair factors and/or triggers senescence or programmed cell death. Alterations in chromatin structure are implicated in the initiation ...
    • TSC1 Promotes B Cell Maturation but Is Dispensable for Germinal Center Formation. 

      Carico, Z; Ci, X; Deng, X; Hopper, K; Kelsoe, Garnett; Kuraoka, M; Qiu, Y; ... (11 authors) (PLoS One, 2015)
      Accumulating evidence indicates that the tuberous sclerosis complex 1 (TSC1), a tumor suppressor that acts by inhibiting mTOR signaling, plays an important role in the immune system. We report here that TSC1 differentially ...