Browsing by Subject "Myelin Sheath"

EAE cerebrospinal fluid augments in vitro phagocytosis and metabolism of CNS myelin by macrophages.

Sommer, MA; Forno, LS; Smith, ME (J Neurosci Res, 1992-07)

Previous studies from this laboratory have shown that CNS myelin is phagocytized and metabolized by cultured rat macrophages to a much larger extent when myelin is pretreated with serum containing antibodies to ...

Gene products promoting remyelination are up-regulated in a cell therapy product manufactured from banked human cord blood.

Scotland, Paula; Buntz, Susan; Noeldner, Pamela; Saha, Arjun; Gentry, Tracy; Kurtzberg, Joanne; Balber, Andrew E (Cytotherapy, 2017-06)

<h4>Background aims</h4>DUOC-01, a cell product being developed to treat demyelinating conditions, is composed of macrophages that arise from CD14+ monocytes in the mononuclear cell (MNC) population of banked cord blood ...

Induction of anti-myelin antibodies in EAE and their possible role in demyelination.

Sadler, RH; Sommer, MA; Forno, LS; Smith, ME (J Neurosci Res, 1991-12)

Experimental allergic encephalomyelitis is characterized by invasion of lymphocytes and macrophages into the central nervous system resulting in inflammation, edema, and demyelination. Sera from Lewis rats from 7-95 days ...