Browsing by Subject "Myeloid Cells"
Now showing items 1-6 of 6
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A PK2/Bv8/PROK2 antagonist suppresses tumorigenic processes by inhibiting angiogenesis in glioma and blocking myeloid cell infiltration in pancreatic cancer.
(2011)In many cancer types, infiltration of bone marrow-derived myeloid cells in the tumor microenvironment is often associated with enhanced angiogenesis and tumor progression, resulting in poor prognosis. The polypeptide chemokine ... -
Autophagy enhances NFκB activity in specific tissue macrophages by sequestering A20 to boost antifungal immunity.
(Nat Commun, 2015-01-22)Immune responses must be well restrained in a steady state to avoid excessive inflammation. However, such restraints are quickly removed to exert antimicrobial responses. Here we report a role of autophagy in an early host ... -
Essential cell-extrinsic requirement for PDIA6 in lymphoid and myeloid development.
(The Journal of experimental medicine, 2020-04)In a forward genetic screen of N-ethyl-N-nitrosourea (ENU)-induced mutant mice for aberrant immune function, we identified mice with a syndromic disorder marked by growth retardation, diabetes, premature death, and severe ... -
Inhibition of estrogen signaling in myeloid cells increases tumor immunity in melanoma.
(The Journal of clinical investigation, 2021-12)Immune checkpoint blockade (ICB) therapies have significantly prolonged patient survival across multiple tumor types, particularly in melanoma. Interestingly, sex-specific differences in response to ICB have been observed, ... -
Single cell transcriptomics of mouse kidney transplants reveals a myeloid cell pathway for transplant rejection.
(JCI insight, 2020-10)Myeloid cells are increasingly recognized as major players in transplant rejection. Here, we used a murine kidney transplantation model and single cell transcriptomics to dissect the contribution of myeloid cell subsets ... -
Skewing of the population balance of lymphoid and myeloid cells by secreted and intracellular osteopontin.
(Nature immunology, 2017-09)The balance of myeloid populations and lymphoid populations must be well controlled. Here we found that osteopontin (OPN) skewed this balance during pathogenic conditions such as infection and autoimmunity. Notably, two ...
