Browsing by Subject "NLRP3 inflammasome"

Calcium Pyrophosphate And Monosodium Urate Activate The NLRP3 Inflammasome Within Bladder Urothelium Via Reactive Oxygen Species And TXNIP.

Harper, Shelby N; Leidig, Patrick D; Hughes, Francis M; Jin, Huixia; Purves, J Todd (Research and reports in urology, 2019-01)

Objective:To investigate the in vitro activation of the NLRP3 inflammasome within bladder urothelium by stone-forming components. Further, to describe the contributions of reactive oxygen species (ROS) and thioredoxin-interacting ...

Genetic variants of BIRC3 and NRG1 in the NLRP3 inflammasome pathway are associated with non-small cell lung cancer survival.

Tang, Dongfang; Liu, Hongliang; Zhao, Yuchen; Qian, Danwen; Luo, Sheng; Patz, Edward F; Su, Li; ... (11 authors) (American journal of cancer research, 2020-01)

The nod-like receptor protein 3 (NLRP3) is one of the most characterized inflammasomes, and its genetic variation and functional dysregulation are involved in pathogenesis of several cancers. To systematically evaluate the ...

Overcoming Immunotherapy Resistance by Targeting the Tumor-Intrinsic NLRP3-HSP70 Signaling Axis.

Theivanthiran, Balamayooran; Haykal, Tarek; Cao, Linda; Holtzhausen, Alisha; Plebanek, Michael; DeVito, Nicholas C; Hanks, Brent A (Cancers, 2021-09-23)

The tumor-intrinsic NOD-like receptor family, pyrin-domain-containing-3 (NLRP3) inflammasome, plays an important role in regulating immunosuppressive myeloid cell populations in the tumor microenvironment (TME). While prior ...