Now showing items 1-4 of 4

    • A miR-34a-Numb Feedforward Loop Triggered by Inflammation Regulates Asymmetric Stem Cell Division in Intestine and Colon Cancer. 

      Bu, P; Wang, L; Chen, KY; Srinivasan, T; Murthy, PK; Tung, KL; Varanko, AK; ... (12 authors) (Cell Stem Cell, 2016-02-04)
      Emerging evidence suggests that microRNAs can initiate asymmetric division, but whether microRNA and protein cell fate determinants coordinate with each other remains unclear. Here, we show that miR-34a directly suppresses ...
    • c-Myc is required for maintenance of glioma cancer stem cells. 

      Hjelmeland, AB; Lathia, JD; Li, Z; McLendon, Roger E; Rich, JN; Wang, H; Wang, J; ... (8 authors) (PLoS One, 2008)
      BACKGROUND: Malignant gliomas rank among the most lethal cancers. Gliomas display a striking cellular heterogeneity with a hierarchy of differentiation states. Recent studies support the existence of cancer stem cells in ...
    • Targeting A20 decreases glioma stem cell survival and tumor growth. 

      Eyler, C; Heddleston, J; Hjelmeland, AB; Lathia, JD; Lee, J; Macswords, J; McLendon, Roger E; ... (11 authors) (PLoS Biol, 2010-02-23)
      Glioblastomas are deadly cancers that display a functional cellular hierarchy maintained by self-renewing glioblastoma stem cells (GSCs). GSCs are regulated by molecular pathways distinct from the bulk tumor that may be ...
    • The role of stem cells in airway repair: implications for the origins of lung cancer. 

      Mulvihill, Michael; Kratz, JR; Pham, P; Jablons, DM; He, B (Chin J Cancer, 2013-02)
      Lung cancer is the leading cause of cancer-related deaths worldwide. Recently, advancements in our ability to identify and study stem cell populations in the lung have helped researchers to elucidate the central role that ...