Browsing by Subject "Neuromuscular Junction"

Now showing items 1-3 of 3

    • A Genetic Analysis of the MicroRNA miR-133b in the Mammalian Nervous System 

      Heyer, Mary Patricia (2011)
      The development and function of the nervous system relies on complex regulation of gene expression programs. MicroRNAs (miRNAs) are small RNAs that have diverse functions in mammalian development and disease. In concert ...

    • Adjunctive β2-agonists reverse neuromuscular involvement in murine Pompe disease. 

      Li, Songtao; Sun, Baodong; Nilsson, Mats I; Bird, Andrew; Tarnopolsky, Mark A; Thurberg, Beth L; Bali, Deeksha; ... (8 authors) (FASEB J, 2013-01)
      Pompe disease has resisted enzyme replacement therapy with acid α-glucosidase (GAA), which has been attributed to inefficient cation-independent mannose-6-phosphate receptor (CI-MPR) mediated uptake. We evaluated β2-agonist ...

    • Mitochondrial ROS cause motor deficits induced by synaptic inactivity: Implications for synapse pruning. 

      Sidlauskaite, Eva; Gibson, Jack W; Megson, Ian L; Whitfield, Philip D; Tovmasyan, Artak; Batinic-Haberle, Ines; Murphy, Michael P; ... (9 authors) (Redox biology, 2018-06)
      Developmental synapse pruning refines burgeoning connectomes. The basic mechanisms of mitochondrial reactive oxygen species (ROS) production suggest they select inactive synapses for pruning: whether they do so is unknown. ...