Now showing items 1-13 of 13

    • Attenuation of inflammatory events in human intervertebral disc cells with a tumor necrosis factor antagonist. 

      Sinclair, SM; Shamji, MF; Chen, J; Jing, L; Richardson, WJ; Brown, CR; Fitch, RD; ... (8 authors) (Spine (Phila Pa 1976), 2011-07-01)
      STUDY DESIGN: The inflammatory responses of primary human intervertebral disc (IVD) cells to tumor necrosis factor α (TNF-α) and an antagonist were evaluated in vitro. OBJECTIVE: To investigate an ability for soluble TNF ...
    • Cancer Stem Cells in Brain Tumors: Identification of Critical Biological Effectors 

      Eyler, Christine Elissa (2010)
      Human cancer is a leading cause of morbidity and mortality in the developed world. Contrary to the classical model in which tumors are homogeneously composed of malignant cells, accumulating evidence suggests that subpopulations ...
    • Fiber type-specific nitric oxide protects oxidative myofibers against cachectic stimuli. 

      Yu, Z; Li, P; Zhang, M; Hannink, M; Stamler, JS; Yan, Z (PLoS One, 2008-05-07)
      Oxidative skeletal muscles are more resistant than glycolytic muscles to cachexia caused by chronic heart failure and other chronic diseases. The molecular mechanism for the protection associated with oxidative phenotype ...
    • Increased in vivo glucose recovery via nitric oxide release. 

      Klitzman, Bruce; Le, NN; Nichols, Scott P; Schoenfisch, MH (Anal Chem, 2011-02-15)
      The in vivo glucose recovery of subcutaneously implanted nitric oxide (NO)-releasing microdialysis probes was evaluated in a rat model using saturated NO solutions to steadily release NO. Such methodology resulted in a constant ...
    • Long-term dynamics of death rates of emphysema, asthma, and pneumonia and improving air quality. 

      Abernethy, Amy Pickar; Akushevich, Igor; Holman, S; Kravchenko, J; Lyerly, Herbert Kim; Ross, WG (Int J Chron Obstruct Pulmon Dis, 2014)
      BACKGROUND: The respiratory tract is a major target of exposure to air pollutants, and respiratory diseases are associated with both short- and long-term exposures. We hypothesized that improved air quality in North Carolina ...
    • Mitochondrial Quality Control as a Therapeutic Target. 

      Piantadosi, Claude Anthony; Suliman, Hagir B (Pharmacol Rev, 2016-01)
      In addition to oxidative phosphorylation (OXPHOS), mitochondria perform other functions such as heme biosynthesis and oxygen sensing and mediate calcium homeostasis, cell growth, and cell death. They participate in cell ...
    • Modified INOvent for delivery of inhaled nitric oxide during cardiac MRI. 

      Devendra, Ganesh P; Flamm, Scott D; Hart, Stephen A; Kim, YY; Krasuski, Richard Andrew; Setser, RM (Magn Reson Imaging, 2011-10)
      BACKGROUND: The aim of this study was to assess the feasibility of delivering NO through a modified system to allow clearance of the magnetic field and thus compatibility with cardiac magnetic resonance (CMR). Nitric oxide ...
    • PINOT NOIR: pulmonic insufficiency improvement with nitric oxide inhalational response. 

      Arruda, J; Bolen, M; Boonyasirinant, T; Devendra, Ganesh P; Flamm, Scott D; Hart, Stephen A; Kalahasti, V; ... (11 authors) (J Cardiovasc Magn Reson, 2013-09-04)
      BACKGROUND: Tetralogy of Fallot (TOF) repair and pulmonary valvotomy for pulmonary stenosis (PS) lead to progressive pulmonary insufficiency (PI), right ventricular enlargement and dysfunction. This study assessed whether ...
    • Purification and Characterization of Novel Denitrosylases from Yeast and Mammals 

      Anand, Puneet (2012)
      S-nitrosylation, the prototypic mechanism of redox-based signal transduction, involves the covalent attachment of a nitrogen monoxide group to a Cys-thiol side chain. S-nitrosylation of proteins has been demonstrated to ...
    • Response to inhaled nitric oxide predicts survival in patients with pulmonary hypertension. 

      Bashore, TM; Devendra, Ganesh P; Harrison, JK; Hart, Stephen A; Krasuski, Richard Andrew; Wang, Andrew (J Card Fail, 2011-04)
      OBJECTIVE: To examine the ability of vasodilator response to predict survival in a diverse cohort of patients with pulmonary hypertension (PH). PATIENTS & METHODS: A total of 214 consecutive treatment-naive patients referred ...
    • Scaffold-free, Human Mesenchymal Stem Cell-Based Tissue Engineered Blood Vessels. 

      Atchison, L; Chen, Z; Fai Chan, H; Ji, H; Jung, Y; Klitzman, Bruce; Leong, KW; ... (8 authors) (Sci Rep, 2015-10-12)
      Tissue-engineered blood vessels (TEBV) can serve as vascular grafts and may also play an important role in the development of organs-on-a-chip. Most TEBV construction involves scaffolding with biomaterials such as collagen ...
    • The effect of nitric oxide surface flux on the foreign body response to subcutaneous implants. 

      Brown, NL; Klitzman, Bruce; Koh, A; Nichols, Scott P; Riccio, DA; Rose, MB; Schoenfisch, MH; ... (9 authors) (Biomaterials, 2012-09)
      Although the release of nitric oxide (NO) from biomaterials has been shown to reduce the foreign body response (FBR), the optimal NO release kinetics and doses remain unknown. Herein, polyurethane-coated wire substrates ...
    • Treatment-related biomarkers in pulmonary hypertension. 

      Swaminathan, AC; Dusek, AC; McMahon, TJ (Am J Respir Cell Mol Biol, 2015-06)
      Significant advances in the treatment of pulmonary arterial hypertension (PAH) over the last two decades have led to the introduction of multiple classes of oral therapy, but the disease remains devastating for many patients. ...