Browsing by Subject "Notch"
Now showing items 1-4 of 4
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Activation of developmental signaling pathways in hematopoietic stem cell regeneration
(2010)The homeostatic hematopoietic stem cell compartment is comprised of quiescent long term self renewing stem cells and cycling short term stem cells with finite renewal potential. To study the molecular mechanisms governing ... -
Cell Lineage Specification during Mouse Embryonic Gonad Development
(2017)The mouse embryonic gonad provides an outstanding model to study the complex mechanisms involved in cell fate specification and maintenance. At the bipotential stage, both XX and XY gonads are capable of becoming testes ... -
Deciphering the Role of the YAP Oncoprotein in Ras-driven Rhabdomyosarcoma Tumorigenesis
(2017)Rhabdomyosarcoma (RMS), the most common soft tissue sarcoma in children and adolescents, is characterized by skeletal muscle features. The Ras-driven subset, which includes the embryonal (eRMS) and pleomorphic (pRMS) histologic ... -
The Role of Notch Signaling in Type-2 Immunity
(2018)Over 1.5 billion individuals are infected with intestinal helminths worldwide, with a majority of those infected living in developing nations. In developed nations intestinal helminth infections are very rare, while incidences ...
