Now showing items 1-2 of 2

    • c-Myc is required for maintenance of glioma cancer stem cells. 

      Wang, J; Wang, H; Li, Z; Wu, Q; Lathia, JD; McLendon, RE; Hjelmeland, AB; ... (8 authors) (PLoS One, 2008)
      BACKGROUND: Malignant gliomas rank among the most lethal cancers. Gliomas display a striking cellular heterogeneity with a hierarchy of differentiation states. Recent studies support the existence of cancer stem cells in ...
    • Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2. 

      Meloni, AR; Fralish, GB; Kelly, P; Salahpour, A; Chen, JK; Wechsler Reya, RJ; Lefkowitz, RJ; ... (8 authors) (Mol Cell Biol, 2006-10)
      Deregulation of the Sonic hedgehog pathway has been implicated in an increasing number of human cancers. In this pathway, the seven-transmembrane (7TM) signaling protein Smoothened regulates cellular proliferation ...