Now showing items 1-2 of 2

    • c-Myc is required for maintenance of glioma cancer stem cells. 

      Hjelmeland, AB; Lathia, JD; Li, Z; McLendon, Roger E; Rich, JN; Wang, H; Wang, J; ... (8 authors) (PLoS One, 2008)
      BACKGROUND: Malignant gliomas rank among the most lethal cancers. Gliomas display a striking cellular heterogeneity with a hierarchy of differentiation states. Recent studies support the existence of cancer stem cells in ...
    • Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2. 

      Caron, MG; Chen, JK; Fralish, GB; Kelly, P; Lefkowitz, Robert J; Meloni, AR; Salahpour, A; ... (8 authors) (Mol Cell Biol, 2006-10)
      Deregulation of the Sonic hedgehog pathway has been implicated in an increasing number of human cancers. In this pathway, the seven-transmembrane (7TM) signaling protein Smoothened regulates cellular proliferation ...