Browsing by Subject "Oncology"
Now showing items 1-20 of 100
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A Collimator Setting Optimization Algorithm for Dual-arc Volumetric Modulated Arc Therapy in Pancreas Stereotactic Body Radiation Therapy
(2019)Purpose: To develop an automatic collimator setting optimization algorithm to improve dosimetric quality of pancreas Volumetric Modulated Arc Therapy (VMAT) plans for Stereotactic Body Radiation Therapy (SBRT). Methods: ... -
A Dosimetric Characterization of Novel Formulations of Presage 3D Dosimeters
(2014)<bold>Purpose:</bold> The purpose of this work is to characterize three novel formulations of a radiochromic material Presage and identify optimal imaging procedures for accurate 3D dosimetry. The dosimetric qualities of ... -
A Model of Lung Tumor Angiogenesis in a Biomimetic Poly(ethylene glycol)-based Hydrogel System
(2016)Tumor angiogenesis is critical to tumor growth and metastasis, yet much is unknown about the role vascular cells play in the tumor microenvironment. A major outstanding challenge associated with studying tumor angiogenesis ... -
A Novel Comprehensive Verification Method for Multifocal RapidArc Radiosurgery Treatments
(2012)<bold>Purpose:</bold> Radiosurgery has become a widely used procedure in the treatment of both solid tumors and secondary metastases in the brain. In cases with multiple brain lesions, isocenters are typically set up for ... -
Aerobic Training-Induced Host Changes Alter Breast Cancer Cell Phenotypes and Tumor Progression
(2015)A growing number of studies have investigated the role of exercise both during and after a breast cancer diagnosis. Observational data suggests that regular endurance exercise is associated with a 20-50% reduction ... -
An Agonist CD27 Antibody for Brain Tumor Immunotherapy
(2017)Glioblastoma (GBM) is a uniformly lethal cancer with an overall survival of less than 15 months. Aggressive standard of care therapies fail to eradicate these tumors and are non-specific, resulting in incapacitating toxicities. ... -
An Exploration of the Feasibility of Combining Radiation Therapy with Psoralen Phototherapy
(2018)Radiation therapy (RT) has been a standard-of-care treatment for many localized cancers for decades. Despite being an effective treatment modality for many clinical presentations, the efficacy of RT against cancer can be ... -
Antibody-mediated Immunotherapy of Brain Tumors
(2017)Conventional therapy for malignant glioma (MG) fails to specifically target tumor cells. In contrast, immunotherapy offers an exquisitely precise approach, and substantial evidence indicates that if appropriately redirected, ... -
Application of Phylogenetic Analysis in Cancer Evolution
(2018)Cancer is a major threat to human health and results in 1 in 6 deaths globally. Despite an extraordinary amount of effort and money spent, eradication or control of advanced disease has not yet been achieved. Understanding ... -
Assessment of Variability in Liver Tumor Contrast in MRI for Radiation Therapy
(2017)Purpose: To investigate the inter-patient and inter-sequence variation in liver tumor contrast in MRI and the feasibility of improving the liver tumor contrast by using an in-house developed multi-source adaptive fusion ... -
B cells and the Antibody-Dependent Immune Response in Cancer and Infection
(2015)B cells and humoral immunity are critical components of an effective immune response. However, B cells are also a significant driver of a variety of autoimmune diseases and can also become malignant. Antibody-mediated B ... -
Beam Angle Optimization for Automated Coplanar IMRT Lung Plans
(2016)Purpose: To investigate the effect of incorporating a beam spreading parameter in a beam angle optimization algorithm and to evaluate its efficacy for creating coplanar IMRT lung plans in conjunction with machine learning ... -
Benchmarking Flattening Filter-Free Photons for IMRT/VMAT using TG119
(2014)Since the publication of TG119 in 2009, new techniques have emerged in the field of radiation therapy including VMAT (Volumetric Arc Therapy) and the FFF (Flattening Filter Free) mode in Varian linear accelerators. Our goal ... -
Bone Morphogenetic Proteins Signal through Smad1/5/8 to induce MET, Smad2 to Specify the Dorsoventral Axis and Smad3 to Facilitate Invasion.
(2013)The bone morphogenetic protein (BMP) signaling pathways have important roles in embryonic development and homeostasis. BMPs have been shown to pattern the dorsoventral axis in zebrafish (<italic>Danio rerio</italic>) early ... -
Cell-Surface GRP78 and its Antibodies: Pathologic and Therapeutic Roles in Cancer
(2010)The chaperone protein GRP78 is primarily expressed in the endoplasmic reticulum, but it is also aberrantly expressed on the surface of cells under pathological conditions. One the cell membrane, GRP78 acts as a signaling ... -
Characterization of a Mouse Model of Soft Tissue Sarcoma: Intraoperative Molecular Imaging and miRNA Regulation of Metastasis
(2013)Soft Tissue Sarcomas are a rare group of mesenchymal tumors with over 50 recognized subtypes. These tumors are a diverse group of malignancies that primarily arise from the connective tissue, fat and muscle. In the United ... -
Characterizing Genetic Drivers of Lymphoma through High-Throughput Sequencing
(2016)The advent of next-generation sequencing, now nearing a decade in age, has enabled, among other capabilities, measurement of genome-wide sequence features at unprecedented scale and resolution. In this dissertation, I describe ... -
Compound haploinsufficiency of Dok2 and Dusp4 promotes lung tumorigenesis.
(The Journal of clinical investigation, 2019-01)Recurrent broad-scale heterozygous deletions are frequently observed in human cancer. Here we tested the hypothesis that compound haploinsufficiency of neighboring genes at chromosome 8p promotes tumorigenesis. By targeting ... -
Consensus Segmentation for Positron Emission Tomography: Development and Applications in Radiation Therapy
(2013)The use of positron emission tomography (PET) in radiation therapy has continued to grow, especially since the development of combined computed tomography (CT) and PET imaging system in the early 1990s. Today, the biggest ... -
Deciphering the Role of the YAP Oncoprotein in Ras-driven Rhabdomyosarcoma Tumorigenesis
(2017)Rhabdomyosarcoma (RMS), the most common soft tissue sarcoma in children and adolescents, is characterized by skeletal muscle features. The Ras-driven subset, which includes the embryonal (eRMS) and pleomorphic (pRMS) histologic ...
