Browsing by Subject "Oncology"
Now showing items 1-20 of 141
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A Collimator Setting Optimization Algorithm for Dual-arc Volumetric Modulated Arc Therapy in Pancreas Stereotactic Body Radiation Therapy
(2019)Purpose: To develop an automatic collimator setting optimization algorithm to improve dosimetric quality of pancreas Volumetric Modulated Arc Therapy (VMAT) plans for Stereotactic Body Radiation Therapy (SBRT). Methods: ... -
A Controlled Breathing Intervention for Women Undergoing MRI-Guided Breast Biopsy: A Randomized Controlled Trial
(2020)Controlled breathing techniques are widely used to help people manage pain, and there is growing interest in using these approaches during painful outpatient medical procedures. The outpatient MRI-guided breast biopsy is ... -
A Dosimetric Characterization of Novel Formulations of Presage 3D Dosimeters
(2014)<bold>Purpose:</bold> The purpose of this work is to characterize three novel formulations of a radiochromic material Presage and identify optimal imaging procedures for accurate 3D dosimetry. The dosimetric qualities of ... -
A General-Purpose Simulator for Evaluating Astronaut Radiation Exposure
(2021)Purpose: Current Monte Carlo simulations modeling space radiation exposure typically use simplistic human phantoms with low anatomical detail and minimal variability in physical characteristics. This thesis describes the ... -
A Model of Lung Tumor Angiogenesis in a Biomimetic Poly(ethylene glycol)-based Hydrogel System
(2016)Tumor angiogenesis is critical to tumor growth and metastasis, yet much is unknown about the role vascular cells play in the tumor microenvironment. A major outstanding challenge associated with studying tumor angiogenesis ... -
A Novel Comprehensive Verification Method for Multifocal RapidArc Radiosurgery Treatments
(2012)<bold>Purpose:</bold> Radiosurgery has become a widely used procedure in the treatment of both solid tumors and secondary metastases in the brain. In cases with multiple brain lesions, isocenters are typically set up for ... -
Aerobic Training-Induced Host Changes Alter Breast Cancer Cell Phenotypes and Tumor Progression
(2015)A growing number of studies have investigated the role of exercise both during and after a breast cancer diagnosis. Observational data suggests that regular endurance exercise is associated with a 20-50% reduction ... -
An Agonist CD27 Antibody for Brain Tumor Immunotherapy
(2017)Glioblastoma (GBM) is a uniformly lethal cancer with an overall survival of less than 15 months. Aggressive standard of care therapies fail to eradicate these tumors and are non-specific, resulting in incapacitating toxicities. ... -
An Exploration of the Feasibility of Combining Radiation Therapy with Psoralen Phototherapy
(2018)Radiation therapy (RT) has been a standard-of-care treatment for many localized cancers for decades. Despite being an effective treatment modality for many clinical presentations, the efficacy of RT against cancer can be ... -
Antibody-mediated Immunotherapy of Brain Tumors
(2017)Conventional therapy for malignant glioma (MG) fails to specifically target tumor cells. In contrast, immunotherapy offers an exquisitely precise approach, and substantial evidence indicates that if appropriately redirected, ... -
Application of Phylogenetic Analysis in Cancer Evolution
(2018)Cancer is a major threat to human health and results in 1 in 6 deaths globally. Despite an extraordinary amount of effort and money spent, eradication or control of advanced disease has not yet been achieved. Understanding ... -
Assessment of Variability in Liver Tumor Contrast in MRI for Radiation Therapy
(2017)Purpose: To investigate the inter-patient and inter-sequence variation in liver tumor contrast in MRI and the feasibility of improving the liver tumor contrast by using an in-house developed multi-source adaptive fusion ... -
Association of elevated serumfree light chains with chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis.
(Blood cancer journal, 2019-08-05)Chronic lymphocytic leukemia (CLL) and its precursor, monoclonal B-cell lymphocytosis (MBL), are heritable. Serumfree light-chain (sFLC) measures are a prognostic factor for CLL, but their role in susceptibility to CLL is ... -
B cells and the Antibody-Dependent Immune Response in Cancer and Infection
(2015)B cells and humoral immunity are critical components of an effective immune response. However, B cells are also a significant driver of a variety of autoimmune diseases and can also become malignant. Antibody-mediated B ... -
Beam Angle Optimization for Automated Coplanar IMRT Lung Plans
(2016)Purpose: To investigate the effect of incorporating a beam spreading parameter in a beam angle optimization algorithm and to evaluate its efficacy for creating coplanar IMRT lung plans in conjunction with machine learning ... -
Bench to bedside: A Bispecific Antibody for treating Brain Tumors
(2019)Malignant gliomas are the most common primary brain tumor in adults, with an incidence of five cases per 100,000 persons per year. Grade IV glioblastoma is the most aggressive form and prognosis remains poor despite the ... -
Benchmarking Flattening Filter-Free Photons for IMRT/VMAT using TG119
(2014)Since the publication of TG119 in 2009, new techniques have emerged in the field of radiation therapy including VMAT (Volumetric Arc Therapy) and the FFF (Flattening Filter Free) mode in Varian linear accelerators. Our goal ... -
Bone Morphogenetic Proteins Signal through Smad1/5/8 to induce MET, Smad2 to Specify the Dorsoventral Axis and Smad3 to Facilitate Invasion.
(2013)The bone morphogenetic protein (BMP) signaling pathways have important roles in embryonic development and homeostasis. BMPs have been shown to pattern the dorsoventral axis in zebrafish (<italic>Danio rerio</italic>) early ... -
Cell-Surface GRP78 and its Antibodies: Pathologic and Therapeutic Roles in Cancer
(2010)The chaperone protein GRP78 is primarily expressed in the endoplasmic reticulum, but it is also aberrantly expressed on the surface of cells under pathological conditions. One the cell membrane, GRP78 acts as a signaling ... -
Characterization of a Mouse Model of Soft Tissue Sarcoma: Intraoperative Molecular Imaging and miRNA Regulation of Metastasis
(2013)Soft Tissue Sarcomas are a rare group of mesenchymal tumors with over 50 recognized subtypes. These tumors are a diverse group of malignancies that primarily arise from the connective tissue, fat and muscle. In the United ...
