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Browsing by Subject "Ophthalmology"
Now showing items 1-20 of 29
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A Comprehensive Framework for Adaptive Optics Scanning Light Ophthalmoscope Image Analysis
(2019)Diagnosis, prognosis, and treatment of many ocular and neurodegenerative diseases, including achromatopsia (ACHM), require the visualization of microscopic structures in the eye. The development of adaptive optics ophthalmic ... -
AAV Delivery of CFH Constructs for Complement Regulation in the Murine Eye
(2022)Age-related macular degeneration (AMD), a major cause of irreversible vision loss in elderly populations, has been associated genetically with the complement system, and especially with complement factor H (CFH). However, ... -
Angiopoietin-1 is required for Schlemm's canal development in mice and humans.
(The Journal of clinical investigation, 2017-12)Primary congenital glaucoma (PCG) is a leading cause of blindness in children worldwide and is caused by developmental defects in 2 aqueous humor outflow structures, Schlemm's canal (SC) and the trabecular meshwork. We previously ... -
Causes of Childhood Blindness in North Ghana: Results From a School for the Blind in Wa, Upper West Region
(2016)Background: Because most developing countries lack sufficient resources and infrastructure to conduct population-based studies on childhood blindness, it can be difficult to obtain epidemiologically reliable data available ... -
Deep Learning Image Analysis Framework for Clinical Management of Retinal and Corneal Diseases
(2022)Retinal and corneal diseases are the leading causes of global vision impairment. The advent of high‐resolution ophthalmic imaging technology enables the visualization of internal and external structures of the eye, thereby ... -
Development of Extended-Depth Swept Source Optical Coherence Tomography for Applications in Ophthalmic Imaging of the Anterior and Posterior Eye
(2012)Optical coherence tomography (OCT) is a non-invasive optical imaging modality that provides micron-scale resolution of tissue micro-structure over depth ranges of several millimeters. This imaging technique has had a profound ... -
Development of Low-cost Imaging Tools for Screening of Retinal Biomarkers in Alzheimer’s Disease
(2021)Alzheimer’s disease (AD) is a neurodegenerative disease currently affecting 5.8 million Americans and more than 50 million people worldwide. It is a progressive disease that destroys cognitive functions, leading to dementia. ... -
Development of Multi-modal and Super-resolved Retinal Imaging Systems
(2016)Advancements in retinal imaging technologies have drastically improved the quality of eye care in the past couple decades. Scanning laser ophthalmoscopy (SLO) and optical coherence tomography (OCT) are two examples of critical ... -
Differential Expression of Coding and Long Noncoding RNAs in Keratoconus-Affected Corneas.
(Investigative ophthalmology & visual science, 2018-06)Keratoconus (KC) is the most common corneal ectasia. We aimed to determine the differential expression of coding and long noncoding RNAs (lncRNAs) in human corneas affected with KC.From the corneas of 10 KC patients and ... -
Elucidating the Genetic Basis of Fuchs Endothelial Corneal Dystrophy
(2012)Fuchs endothelial corneal dystrophy (FECD) is a complex, late-onset disorder that is a frequent indication for corneal transplantation and affects women more frequently than men. Although linkage and association studies ... -
Enhanced Vasculature Imaging of the Retina Using Optical Coherence Tomography
(2013)Optical coherence tomography (OCT) is a non-invasive imaging modality that uses low coherence interferometry to generate three-dimensional datasets of a sample's structure. OCT has found tremendous clinical applications ... -
Enhancing the Visualization of the Peripheral Retina with Wide Field-of-View Optical Coherence Tomography
(2016)The goal of my Ph.D. thesis is to enhance the visualization of the peripheral retina using wide-field optical coherence tomography (OCT) in a clinical setting.OCT has gain widespread adoption in clinical ophthalmology due ... -
Future requirements for and supply of ophthalmologists for an aging population in Singapore.
(Hum Resour Health, 2015-11-17)BACKGROUND: Singapore's population, as that of many other countries, is aging; this is likely to lead to an increase in eye diseases and the demand for eye care. Since ophthalmologist training is long and expensive, early ... -
Graph Theory and Dynamic Programming Framework for Automated Segmentation of Ophthalmic Imaging Biomarkers
(2014)Accurate quantification of anatomical and pathological structures in the eye is crucial for the study and diagnosis of potentially blinding diseases. Earlier and faster detection of ophthalmic imaging biomarkers also leads ... -
Imaging at the Limits: Segmentation Error Bounds and High Resolution Retinal Imaging Systems
(2018)The human retina is essential to quality of life and therefore a topic of intense clinical and research interest. The combination of this interest with modern biophotonics has yielded a number of technological and medical ... -
Increasing Glaucoma Detection in Roatán, Honduras: The Value of Education and Intraocular Pressure Screenings
(2023-04-11)Glaucoma is an ocular neuropathy that damages the optic nerve, leading to vision loss and blindness. Insidious in its presentation and difficult to diagnose, glaucoma is asymptomatic until irreversible harm is caused. Accounting ... -
Inherited Retinal Degenerations: Current Landscape and Knowledge Gaps
(Translational Vision Science & Technology, 2018-07-18) -
Investigating the Histopathology and Co-prevalence of Age-related Macular Degeneration and Alzheimer's Disease
(2017-05-08)PURPOSE: To investigate the parallels between age-related macular degeneration (AMD) and Alzheimer’s disease (AD) by 1) characterizing the distribution of macrophages in the retina and choroid of human post-mortem eyes ... -
LXRs regulate features of age-related macular degeneration and may be a potential therapeutic target.
(JCI insight, 2020-01-16)Effective treatments and animal models for the most prevalent neurodegenerative form of blindness in elderly people, called age-related macular degeneration (AMD), are lacking. Genome-wide association studies have identified ... -
Molecular Dissection of Multifunctional Proteins in Rod Outer Segments
(2011)Rod photoreceptors are specialized neurons responsible for capturing photons and translating visual information into electrical signals. Visual signal transduction in rods is confined to the unique outer segment organelle, ...
