Browsing by Subject "Opioid Peptides"

Effects of nociceptin (13-17) in pain modulation at supraspinal level in mice.

Chen, Li-Xiang; Wang, Zhuan-Zi; Wu, Hua; Fang, Quan; Chen, Yong; Wang, Rui (Neurosci Lett, 2002-10-11)

This work was designed to observe the effects of nociceptin(13-17), one of the main metabolites of nociceptin (also termed orphanin FQ), in pain modulation at supraspinal level in mice. Intracerebroventricular (i.c.v.) ...

Preemptive intrathecal administration of endomorphins relieves inflammatory pain in male mice via inhibition of p38 MAPK signaling and regulation of inflammatory cytokines.

Zhang, Ting; Zhang, Nan; Zhang, Run; Zhao, Weidong; Chen, Yong; Wang, Zilong; Xu, Biao; ... (14 authors) (Journal of neuroinflammation, 2018-11-15)

BACKGROUND:Preemptive administration of analgesic drugs reduces perceived pain and prolongs duration of antinociceptive action. Whereas several lines of evidence suggest that endomorphins, the endogenous mu-opioid agonists, ...

Study in vitro and in vivo of nociceptin/orphanin FQ(1-13)NH2 analogues substituting N-Me-Gly for Gly2 or Gly3.

Chen, Li-xiang; Fang, Quan; Chen, Qiang; Guo, Jia; Wang, Zhuan-zi; Chen, Yong; Wang, Rui (Peptides, 2004-08)

In the present study, two analogues containing N-Me-Gly (Sarcosine, Sar) were synthesized to further investigate the structural-activity relationships of orphanin FQ/nociceptin (OFQ/NC, NC). The replacement of Gly(2) or ...