Browsing by Subject "Organic chemistry"
Now showing items 1-20 of 46
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Advances in Selectivity of the Suzuki-Miyaura and Hofmann-Löffler-Freytag Reactions
(2019)The design of synthetic transformations that proceed selectively in the presence of multiple sites of similar chemical reactivity has been a long-standing challenge. Cross-coupling and C–H functionalization processes have ... -
An Umpolung Approach to the α-Functionalization of Ketones and Aldehydes
(2011)The α-alkylation of N-sulfonyl hydrazones via in situ-derived azoalkenes provides an umpolung approach to ketone α-alkylation that has considerable potential with regard to catalysis and the direct incorporation ... -
Chemical Biology Approaches to Combat Parkinson’s Disease
(2018)Parkinson's disease (PD) is a debilitating neurodegenerative disease of the central nervous system characterized by loss of striatal dopaminergic projections from the substantia nigra. Although there is no known cure for ... -
Controlling and Exploiting Spiropyran-based Mechanochromism
(2019)When mechanical force is applied to synthetic materials, polymer chains becomehighly strained, leading to bond scission and ultimately material failure. Over the lastdecade or so, work in the field of polymer mechanochemistry ... -
Copper-Catalyzed 1,2-Aminocarbonation of Unactivated Alkenes Utilizing O-Benzoylhydroxylamines
(2022)Alkene difunctionalization is a powerful synthetic method that introduces two distinct functional groups simultaneously, which can transform simple alkenes feedstock into richly functionalized valuable skeletons. With the ... -
Copper-Catalyzed Amino Oxygenation of Alkenes and Dienes: A Novel Amino-Initiation Pathway Using O-Benzoylhydroxylamines
(2018)Nitrogen-containing compounds, specifically the 1,2-oxyamino moiety, are of vital importance to modern pharmaceuticals, natural products, and agrochemicals. 1,2-Difunctionalization of alkenes offers an efficient approach ... -
Copper-Catalyzed Electrophilic Amination of sp2 and sp3 C-H Bonds
(2015)The wide presence of C-N bonds in biologically and pharmaceutically important compounds continues to drive the development of new C-N bond-forming transformations. Among the different strategies, electrophilic amination ... -
Design and Synthesis of Natural and Unnatural Macrocycles
(2019)Macrocycles have received growing appreciation for their potential in probing a broader biological space, and there are a significant number of bioactive macrocycles in nature. In addition, a macrocyclic scaffold provides ... -
!Development of small molecule therapeutics against anti-infectious and anti-cancer drug resistance via structure-based drug design
(2022)!Drug discovery typically involves structure-based drug design based on three-dimensional protein structures and hit/lead compound identification and optimization. Herein, this technique was used to overcome several obstacles ... -
Direct and Modular Access to Functionalized Arenes and Cyclohexenes Mediated by Deprotonative C–H Zincation
(2021)Poly-substituted arenes are valuable skeletons and widespread in pharmaceuticals, agrochemicals, and functional materials. In the design and development of novel functional arenes, the major bottleneck lies in their synthetic ... -
Direct Carbon-Carbon Bond Formation via Base Mediated and Reductive Soft Enolization of Thioesters, the First Asymmetric Total Synthesis of (+)- and (-)-Clusianone, and Progress Toward the Asymmetric Total Synthesis of Brasilicardin A
(2012)Three methodology studies and two total synthesis endeavors are presented. First, a study of Lewis acid and hydrogen bond mediated soft enolization of thioesters and their addition to imines in the Mannich reaction is reported. ... -
Evaluation of Complex Biocatalysis in Aqueous Solution. Part I: Efforts Towards a Biophysical Perspective of the Cellulosome; Part II: Experimental Determination of Methonium Desolvation Thermodynamics
(2014)The intricate interplay of biomolecules acting together, rather than alone, provides insight into the most basic of cellular functions, such as cell signaling, metabolism, defense, and, ultimately, the creation of life. ... -
Gold(I)-Catalyzed Enantioselective Hydroamination of Unactivated Alkenes
(2012)Numerous methodologies for efficient formation of carbon-nitrogen bonds have been developed over the decades due to the widespread importance of nitrogen containing compounds in pharmaceuticals and bulk commercial chemicals. ... -
Harnessing the Reactivity of Sulfamate Esters and Sulfamides in Photoredox-Mediated Bond-Forming Reactions
(2020)Advancements in photocatalysis have enabled access to previously inaccessible intermediates, and have allowed for the development of innovative strategies for bond-formation. By employing a series of metal polypyridyl complexes, ... -
Harnessing the Reactivity of Sulfamate Esters and Sulfamides to Enable Position-Selective C-H Halogenation Processes
(2019)Synthetic technologies that enable transformation of typically inert carbon–hydrogen (C–H) bonds into diverse functional groups have streamlined access to complex molecules. These processes, defined as C–H functionalization ... -
Harnessing the Reactivity of Sulfamate Esters and Sulfamides to Enable Position-Selective C-H Halogenation Processes
(2019)Synthetic technologies that enable transformation of typically inert carbon–hydrogen (C–H) bonds into diverse functional groups have streamlined access to complex molecules. These processes, defined as C–H functionalization ... -
I. Design, Synthesis, and Biological Characterization of Subglutinol A Analogs II. Synthetic Efforts Towards the Total Synthesis of RhodojaponinB
(2019)Natural products have a significant influence on the development of chemical treatments for diseases as well as the exploration of biological pathways and are still a major pipeline for novel drug discovery. However, their ... -
I. Development of sulfonyl piperazine LpxH inhibitors against multi-drug resistant Gram-negative bacteria II. Exploration towards new TRPM8 agonists for dry eye disease
(2023)The discovery of new drug scaffolds is a time-consuming and costly process. As new technologies are developed and implemented into the drug discovery process, these costs are being lessened. Of these methods, computer-aided ... -
I. Formal Synthesis of SCH 351448. II. Synthesis and Characterization of Largazole Analogues.
(2012)Part I: Extensive studies for treating hypercholesterolemia, one of the major causes of human morbidity throughout the world, have led to the development of statin drugs-the most prevalent drug prescribed today. In addition ... -
I. Synthetic Progress Towards the Total Synthesis of Rhodojaponin III II. Design and Synthesis of Novel ENT Inhibitors
(2022)Affecting 1 in 5 Americans, chronic pain has become the most common reason individuals seek out medical care. Those suffering from daily pain often endure mobile restrictions, anxiety, depression, and an overall reduced ...
