Browsing by Subject "Organophosphonates"

Brincidofovir for Asymptomatic Adenovirus Viremia in Pediatric and Adult Allogeneic Hematopoietic Cell Transplant Recipients: A Randomized Placebo-Controlled Phase II Trial.

Grimley, Michael S; Chemaly, Roy F; Englund, Janet A; Kurtzberg, Joanne; Chittick, Gregory; Brundage, Thomas M; Bae, Andrew; ... (9 authors) (Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2017-03)

Adenovirus infection in immunocompromised patients contributes to significant morbidity and mortality, especially after allogeneic hematopoietic cell transplantation (HCT). Brincidofovir (BCV, CMX001) is an orally bioavailable ...

Lopinavir/ritonavir monotherapy after virologic failure of first-line antiretroviral therapy in resource-limited settings.

Bartlett, John A; Ribaudo, Heather J; Wallis, Carole L; Aga, Evgenia; Katzenstein, David A; Stevens, Wendy S; Norton, Michael R; ... (14 authors) (AIDS, 2012-07-17)

OBJECTIVE: To evaluate virologic response rates of lopinavir/ritonavir (LPV/r) monotherapy as second-line antiretroviral treatment (ART) among adults in resource-limited settings (RLSs). DESIGN: An open-label pilot study ...

Safety and efficacy of CMX001 as salvage therapy for severe adenovirus infections in immunocompromised patients.

Florescu, Diana F; Pergam, Steven A; Neely, Michael N; Qiu, Fang; Johnston, Christine; Way, SingSing; Sande, Jane; ... (18 authors) (Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2012-05)

No therapeutic agent has yet been established as the definitive therapy for adenovirus infections. We describe the clinical experience of 13 immunocompromised patients who received CMX001 (hexadecyloxypropyl cidofovir), ...