Browsing by Subject "Osteoarthritis"
Now showing items 1-20 of 26
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A flexible statistical model for alignment of label-free proteomics data--incorporating ion mobility and product ion information.
(BMC Bioinformatics, 2013-12-16)BACKGROUND: The goal of many proteomics experiments is to determine the abundance of proteins in biological samples, and the variation thereof in various physiological conditions. High-throughput quantitative proteomics, ... -
Altered trabecular bone structure and delayed cartilage degeneration in the knees of collagen VI null mice.
(PLoS One, 2012)Mutation or loss of collagen VI has been linked to a variety of musculoskeletal abnormalities, particularly muscular dystrophies, tissue ossification and/or fibrosis, and hip osteoarthritis. However, the role of collagen ... -
Association between general joint hypermobility and knee, hip, and lumbar spine osteoarthritis by race: a cross-sectional study.
(Arthritis research & therapy, 2018-04-18)BACKGROUND:Osteoarthritis (OA) prevalence differs by race. General joint hypermobility (GJH) may be associated with OA, but differences by race are not known. This community-based study examined the frequency of GJH and ... -
Biomarkers and proteomic analysis of osteoarthritis.
(Matrix Biol, 2014-10)Our friend and colleague, Dr. Dick Heinegård, contributed greatly to the understanding of joint tissue biochemistry, the discovery and validation of arthritis-related biomarkers and the establishment of methodology for proteomic ... -
Cartilage mechanics in the guinea pig model of osteoarthritis studied with an osmotic loading method.
(Osteoarthritis and cartilage, 2004-05)To determine the material properties of articular cartilage in the Hartley guinea pig model of spontaneous osteoarthritis.Cartilage-bone samples from the medial femoral condyle and tibial plateau of 12 month-old guinea pig ... -
Development of Mucin Analogues to Inhibit the Growth of Calcium Oxalate Kidney Stones
(2021)Kidney stones disease (KSD) is infamous for the morbidity it renders to an afflicted individual by causing intense pain through abrasions the urinary tract during stone passage and/or by causing increased fluid pressure ... -
Diffusional Properties of Articular Cartilage
(2007-03-14)Articular cartilage is the connective tissue that lines joints and provides a smooth surface for articulation and shock absorption. Osteoarthritis, the progressive degeneration of cartilage, is a painful, debilitating, ... -
Elucidating the Molecular Composition of Cartilage by Proteomics.
(J Proteome Res, 2016-02-05)Articular cartilage consists of chondrocytes and two major components, a collagen-rich framework and highly abundant proteoglycans. Most prior studies defining the zonal distribution of cartilage have extracted proteins ... -
Evaluating intra-articular drug delivery for the treatment of osteoarthritis in a rat model.
(Tissue Eng Part B Rev, 2010-02)Osteoarthritis (OA) is a degenerative joint disease that can result in joint pain, loss of joint function, and deleterious effects on activity levels and lifestyle habits. Current therapies for OA are largely aimed at symptomatic ... -
First qualification study of serum biomarkers as indicators of total body burden of osteoarthritis.
(PLoS One, 2010-03-17)BACKGROUND: Osteoarthritis (OA) is a debilitating chronic multijoint disease of global proportions. OA presence and severity is usually documented by x-ray imaging but whole body imaging is impractical due to radiation exposure, ... -
Genetics and Biomarkers of Osteoarthritis and Joint Hypermobility
(2009)Osteoarthritis (OA) is the most common joint disorder causing chronic disability in the world population. By the year 2030, an estimated one fifth of this population will be affected by OA. Although OA is regarded ... -
In vivo Mechanical Metrics for the Quantitative Assessment of Cartilage Health
(2019)Osteoarthritis (OA) is a common joint disorder, affecting over 27 million Americans. OA is characterized by the degeneration of cartilage tissue, and presents clinically with joint pain, stiffness, and limited range of motion. ... -
Micromechanical Properties of the Extracellular and Pericellular Matrices of Articular Cartilage
(2013)The role of articular cartilage in diarthrodial joints is primarily mechanical as the tissue provides a nearly frictionless, load-bearing surface that supports and distributes forces generated during joint loading. Embedded ... -
Non-Invasive Characterization of Cartilage Properties Using MR Imaging
(2015)Osteoarthritis (OA) is a degenerative disease affecting articular cartilage, leading to loss of its structure and function. Early stage OA is characterized by changes in the extracellular matrix (ECM), including a reduction ... -
Posttraumatic osteoarthritis.
(Clin Orthop Relat Res, 2004-06) -
Quantification of the whole-body burden of radiographic osteoarthritis using factor analysis.
(Arthritis Res Ther, 2011)INTRODUCTION: Although osteoarthritis (OA) commonly involves multiple joints, no widely accepted method for quantifying whole-body OA burden exists. Therefore, our aim was to apply factor analytic methods to radiographic ... -
Serum N-propeptide of collagen IIA (PIIANP) as a marker of radiographic osteoarthritis burden.
(PloS one, 2017-01)Cartilage homeostasis relies on a balance of catabolism and anabolism of cartilage matrix. Our goal was to evaluate the burden of radiographic osteoarthritis and serum levels of type IIA procollagen amino terminal propeptide ... -
Sleep Disturbances in Cervical Spondylotic Myelopathy: Prevalence and Postoperative Outcomes-an Analysis From the Quality Outcomes Database.
(Clinical spine surgery, 2023-04)<h4>Study design</h4>Prospective observational study, level of evidence 1 for prognostic investigations.<h4>Objectives</h4>To evaluate the prevalence of sleep impairment and predictors of improved sleep quality 24 months ... -
The Effects of Obesity on Stem Cell Function and the Development of Osteoarthritis
(2015)Obesity due to a high-fat diet is characterized by accumulation of inflammatory macrophages in tissues, leading to chronic low-grade systemic inflammation. Obese individuals also exhibit impaired tissue healing. With a high-fat ... -
The Manual Therapy and Strengthening for the Hip (MASH) Trial: Protocol for a Multisite Randomized Trial of a Subgroup of Older Adults with Chronic Back and Hip Pain.
(Physical therapy, 2021-11-08)<h4>Objective</h4>Chronic low back pain (CLBP) is a disabling and costly condition for older adults that is difficult to properly classify and treat. In a cohort study, a subgroup of older adults with CLBP who had elevated ...
