Now showing items 1-7 of 7

    • Association between DNA damage response and repair genes and risk of invasive serous ovarian cancer. 

      Bentley, RC; Berchuck, Andrew; Clyde, Merlise; Iversen, Edwin S; Marks, JR; Moorman, PG; Palmieri, Rachel T; ... (10 authors) (PLoS One, 2010-04-08)
      BACKGROUND: We analyzed the association between 53 genes related to DNA repair and p53-mediated damage response and serous ovarian cancer risk using case-control data from the North Carolina Ovarian Cancer Study (NCOCS), ...
    • Expression signatures of TP53 mutations in serous ovarian cancers. 

      Baba, T; Barnett, JC; Berchuck, Andrew; Bernardini, MQ; Iversen, Edwin S; Lee, PS; Marks, JR; ... (10 authors) (BMC Cancer, 2010-05-26)
      BACKGROUND: Mutations in the TP53 gene are extremely common and occur very early in the progression of serous ovarian cancers. Gene expression patterns that relate to mutational status may provide insight into the etiology ...
    • Functional annotation signatures of disease susceptibility loci improve SNP association analysis. 

      Clyde, Merlise; Iversen, Edwin S; Lipton, G; Monteiro, AN (BMC Genomics, 2014-05-24)
      BACKGROUND: Genetic association studies are conducted to discover genetic loci that contribute to an inherited trait, identify the variants behind these associations and ascertain their functional role in determining the ...
    • Polymorphisms in the kinesin-like factor 1 B gene and risk of epithelial ovarian cancer in Eastern Chinese women. 

      Jiang, R; Jiang, Z; Shao, ZM; Shi, TY; Sun, MH; Wang, MY; Wei, Q; ... (10 authors) (Tumour Biol, 2015-09)
      The kinesin-like factor 1 B (KIF1B) gene plays an important role in the process of apoptosis and the transformation and progression of malignant cells. Genetic variations in KIF1B may contribute to risk of epithelial ovarian ...
    • Polymorphisms in the SULF1 gene are associated with early age of onset and survival of ovarian cancer. 

      Liu, Zhensheng; Wei, Qingyi; Han, Chan H; Huang, Yu-Jing; Lu, Karen H; Mills, Gordon B; Wang, Li-E (Journal of experimental & clinical cancer research : CR, 2011-01-07)
      SULF1 (sulfatase 1) selectively removes the 6-O-sulphate group from heparan sulfate, changing the binding sites for extracellular growth factors. SULF1 expression has been reported to be decreased in various cancers, including ...
    • Risk of ovarian cancer and inherited variants in relapse-associated genes. 

      Berchuck, Andrew; Couch, FJ; Cunningham, JM; Elliott, EA; Fredericksen, ZS; Fridley, BL; Goode, EL; ... (23 authors) (PLoS One, 2010-01-27)
      BACKGROUND: We previously identified a panel of genes associated with outcome of ovarian cancer. The purpose of the current study was to assess whether variants in these genes correlated with ovarian cancer risk. METHODS ...
    • Survival Benefit of Germline BRCA Mutation is Associated with Residual Disease in Ovarian Cancer. 

      Wei, Qingyi; Shi, Tingyan; Wang, Pan; Tang, Wenbin; Jiang, Rong; Yin, Sheng; Shi, Di; ... (9 authors) (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2018-01)
      BACKGROUND/AIMS:Prognostic value of germline BRCA1 or BRCA2 (gBRCA1/2) mutations in epithelial ovarian cancer (EOC) remains controversial, especially in the estimation of long-term survival. We previously reported the largest ...